Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas.

  title={Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas.},
  author={Saya H. Ebbesen and Maurizio Scaltriti and Carl Uli Bialucha and Natasha Morse and Edward R. Kastenhuber and Hannah Y Wen and Lukas E. Dow and Jos{\'e} Baselga and Scott W Lowe},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={113 11},
Loss of the tumor suppressor gene PTEN is implicated in breast cancer progression and resistance to targeted therapies, and is thought to promote tumorigenesis by activating PI3K signaling. In a transgenic model of breast cancer, Pten suppression using a tetracycline-regulatable short hairpin (sh)RNA cooperates with human epidermal growth factor receptor 2 (HER2/neu), leading to aggressive and metastatic disease with elevated signaling through PI3K and, surprisingly, the mitogen-activated… CONTINUE READING
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