Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

@article{Cristofano2001PtenAP,
  title={Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse},
  author={Antonio Di Cristofano and Marika De Acetis and Andrew T Koff and Carlos Cordon-Cardo and Pier Paolo Pandolfi},
  journal={Nature Genetics},
  year={2001},
  volume={27},
  pages={222-224}
}
The genetic bases underlying prostate tumorigenesis are poorly understood. Inactivation of the tumor-suppressor gene PTEN and lack of p27KIP1 expression have been detected in most advanced prostate cancers. But mice deficient for Cdkn1b (encoding p27Kip1) do not develop prostate cancer. PTEN activity leads to the induction of p27KIP1 expression, which in turn can negatively regulate the transition through the cell cycle. Thus, the inactivation of p27KIP1 may be epistatic to PTEN in the control… CONTINUE READING
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Comparative aspects of development and structure in the prostate

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