PtdIns4KIIα generates endosomal PtdIns(4)P and is required for receptor sorting at early endosomes

@article{Henmi2016PtdIns4KIIGE,
  title={PtdIns4KIIα generates endosomal PtdIns(4)P and is required for receptor sorting at early endosomes},
  author={Yuji Henmi and Y. Morikawa and Natsuko Oe and Narumi Ikeda and A. Fujita and K. Takei and S. Minogue and K. Tanabe},
  journal={Molecular Biology of the Cell},
  year={2016},
  volume={27},
  pages={990 - 1001}
}
  • Yuji Henmi, Y. Morikawa, +5 authors K. Tanabe
  • Published 2016
  • Biology, Medicine
  • Molecular Biology of the Cell
  • PtdIns4KIIα has been implicated in the regulation of endosomal traffic, but the role of its enzymatic activity and the site of its action have not been elucidated. Depletion of PtdIns4KIIα significantly reduced the amount of vesicular PtdIns(4)P on early endosomes, leaving cells with an impaired ability to sort molecules from early endosomes. 
    34 Citations

    Figures and Topics from this paper

    Explore Further: Topics Discussed in This Paper

    Phosphoinositide conversion in endocytosis and the endolysosomal system
    • 54
    • PDF
    A phosphoinositide conversion mechanism for exit from endosomes
    • 92
    • PDF
    Phosphoinositides, Major Actors in Membrane Trafficking and Lipid Signaling Pathways
    • 86
    • PDF
    Phosphatidylinositol Kinases and Phosphatases in Entamoeba histolytica
    • 6
    • PDF
    The Many Roles of Type II Phosphatidylinositol 4‐Kinases in Membrane Trafficking: New Tricks for Old Dogs
    • S. Minogue
    • Biology, Medicine
    • BioEssays : news and reviews in molecular, cellular and developmental biology
    • 2018
    • 12
    • PDF

    References

    SHOWING 1-10 OF 73 REFERENCES
    PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identity
    • 167
    • Highly Influential
    • PDF
    Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway
    • 44
    • PDF
    FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P
    • 505
    Endosomal sorting of VAMP3 is regulated by PI4K2A
    • 40
    • PDF
    OCRL controls trafficking through early endosomes via PtdIns4,5P2‐dependent regulation of endosomal actin
    • 132
    • Highly Influential
    • PDF
    Sorting nexins provide diversity for retromer-dependent trafficking events
    • 274
    EEA1 links PI(3)K function to Rab5 regulation of endosome fusion
    • 1,055
    • Highly Influential
    EHD proteins: key conductors of endocytic transport.
    • 170
    A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi
    • 236
    • PDF