PtdIns (3,4,5) P3 Recruitment of Myo10 Is Essential for Axon Development

  title={PtdIns (3,4,5) P3 Recruitment of Myo10 Is Essential for Axon Development},
  author={Huali Yu and Nannan Wang and Xingda Ju and Yan Yang and Dong Sun and Mingming Lai and Lei Cui and Muhammad Abid Sheikh and Jianhua Zhang and Xingzhi Wang and Xiao-Juan Zhu},
  booktitle={PloS one},
Myosin X (Myo10) with pleckstrin homology (PH) domains is a motor protein acting in filopodium initiation and extension. However, its potential role has not been fully understood, especially in neuronal development. In the present study the preferential accumulation of Myo10 in axon tips has been revealed in primary culture of hippocampal neurons with the aid of immunofluorescence from anti-Myo10 antibody in combination with anti-Tuj1 antibody as specific marker. Knocking down Myo10 gene… CONTINUE READING
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