PtdIns(3,4,5)P3 is a regulator of myosin-X localization and filopodia formation

  title={PtdIns(3,4,5)P3 is a regulator of myosin-X localization and filopodia formation},
  author={Laure Plantard and Antti Arjonen and John G. Lock and Ghasem Nurani and Johanna Ivaska and Staffan Str{\"o}mblad},
  journal={Journal of Cell Science},
  pages={3525 - 3534}
Phosphatidylinositol (3,4,5)-trisphosphate [PtdIns(3,4,5)P3] is a key regulator of cell signaling that acts by recruiting proteins to the cell membrane, such as at the leading edge during cell migration. Here, we show that PtdIns (3,4,5)P3 plays a central role in filopodia formation via the binding of myosin-X (Myo10), a potent promoter of filopodia. We found that the second pleckstrin homology domain (Myo10-PH2) of Myo10 specifically binds to PtdIns(3,4,5)P3, and that disruption of this… 

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