Ptch1 overexpression drives skin carcinogenesis and developmental defects in K14PtchFVB mice

@inproceedings{Kang2013Ptch1OD,
  title={Ptch1 overexpression drives skin carcinogenesis and developmental defects in K14PtchFVB mice},
  author={Hio Chung Kang and Yuichi Wakabayashi and Kuang-Yu Jen and Jian-Hua Mao and Vassilis K Zoumpourlis and Reyno Del Rosario and Allan Balmain},
  booktitle={The Journal of investigative dermatology},
  year={2013}
}
Ptch1 is a key regulator of embryonic development, acting through the sonic hedgehog (SHH) signaling pathway. Ptch1 is best known as a tumor suppressor, as germline or somatic mutations in Ptch1 lead to the formation of skin basal cell carcinomas. Here we show that Ptch1 also acts as a lineage-dependent oncogene, as overexpression of Ptch1 in adult skin in K14Ptch(FVB) transgenic mice synergizes with chemically induced Hras mutations to promote squamous carcinoma development. These effects were… CONTINUE READING
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