Psychotropic substance-seeking: evolutionary pathology or adaptation?

  title={Psychotropic substance-seeking: evolutionary pathology or adaptation?},
  author={Roger J. Sullivan and Edward H. Hagen},
  volume={97 4},
According to a conventional evolutionary perspective, the human propensity for substance use is the product of a 'mismatch' between emotional mechanisms that evolved in a past without pure drugs or direct routes of drug administration, and the occurrence of these phenomena in the contemporary environment. The primary purpose of this review is to assert that, contrary to the conventional view, humans have shared a coevolutionary relationship with psychotropic plant substances that is millions of… 

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