Psychotropic effects of antiepileptic drugs

@article{Ettinger2006PsychotropicEO,
  title={Psychotropic effects of antiepileptic drugs},
  author={Alan B. Ettinger},
  journal={Neurology},
  year={2006},
  volume={67},
  pages={1916 - 1925}
}
  • A. Ettinger
  • Published 12 December 2006
  • Psychology, Medicine
  • Neurology
Background: Mood disorder symptoms are common in patients with epilepsy. Since antiepileptic drugs (AEDs) can affect these symptoms, knowledge of the psychotropic properties of AEDs is crucial. We review most studies of the psychotropic effects of AEDs that have involved potential psychiatric applications and have been reported in the psychiatric literature. Methods: We conducted a comprehensive literature search to identify relevant clinical trial reports on the efficacy of AEDs for mood… 
Antiepileptic drug effects on mood and behavior: Molecular targets
Psychotropic Effects of Anticonvulsant Drugs in Patients with Epilepsy
TLDR
Positive and negative effects of anticonvulsant drugs on mood in patients with epilepsy are discussed, with the use in monotherapy, adopting slow titration schedules and low doses when possible, can significantly reduce the occurrence of treatment emergent adverse events.
A review on antiepileptic drugs-dependent fatigue: pathophysiological mechanisms and incidence.
Lacosamide-induced tactile hallucinations in a patient with complex partial seizures.
TLDR
A case of a youngman who developed severe psychosis with tactile hallucinations following addition of LCM to his AED regimen is presented.
Pharmacogenetic considerations in the treatment of psychiatric disorders
TLDR
Although current data are too sparse to allow the development of guidelines for using pharmacogenetic testing in routine clinical practice, the field of psychiatric pharmacogenetics is rapidly developing and identification of genetic biomarkers that predict therapeutic response and risk of side effects will ultimately help the practitioner to choose effective and safe treatment for patients suffering from psychiatric disorders.
Efficacy and tolerability of antiseizure drugs
  • T. Hakami
  • Medicine, Psychology
    Therapeutic advances in neurological disorders
  • 2021
TLDR
A complete overview of the current state of the literature about the efficacy and tolerability of ASDs is presented and guidance to clinicians about selecting appropriate ASDs for initial treatment of epilepsy according to different seizure types and epilepsy syndromes is provided based on the current literature and recent US and UK practical guidelines.
Role of PhenobaRbitone as an antiePilePtic DRug in 21 st centuRy
TLDR
This chapter pays tribute to this oldest existing anti-convulsant and reviews the scientific literature on the existing knowledge of the role of phenobarbitone as an anti-epileptic drug in the 21st century.
...
...

References

SHOWING 1-10 OF 150 REFERENCES
Antiepileptic Drugs and the Regulation of Mood and Quality of Life (QOL): The Evidence from Epilepsy
TLDR
It is speculated that the amygdala is an important anatomic structure in the cerebral circuits that regulate mood in affective disorders but also in epilepsy, and an effect of AEDs on such circuits aids mood stability in both populations of patients.
Mood effects of antiepileptic drugs
Antiepileptic drugs: indications other than epilepsy.
  • E. Spina, G. Perugi
  • Psychology, Medicine
    Epileptic disorders : international epilepsy journal with videotape
  • 2004
TLDR
The availability of a new generation of AEDs has broadened the therapeutic options in bipolar disorder and Lamotrigine, oxcarbazepine, gabapentin and topiramate appear to be promising in the treatment of refractory bipolar disorder, as a monotherapy as well as in combination with traditional mood stabilizers.
Psychotropic Effects of Antiepileptic Drugs
TLDR
Randomized, double-blind, controlled data on the psychotropic efficacy of antiepileptic drugs are limited mainly to bipolar disorder.
Psychiatric Effects of the Anticonvulsant Regimens
  • T. Rivinus
  • Psychology, Medicine
    Journal of clinical psychopharmacology
  • 1982
TLDR
The current literature on this important bio-psychosocial topic is reviewed with the purpose of suggesting helpful clinical and research approaches to patients treated by such methods.
Antiepileptic, behavioral, and antidepressant effects of adjuvant lamotrigine therapy in drug-resistant epilepsy.
TLDR
Lamotrigine demonstrated significant antiepileptic long-term efficacy, and its positive effects on the mood and quality of life, which surpassed the negative behavioral effects, and contributed highly to the favorable treatment outcome.
Tiagabine in treatment refractory bipolar disorder: a clinical case series.
TLDR
Open add-on tiagabine for treatment-refractory patients with bipolar disorder demonstrated limited efficacy with the majority of patients showing no change or worsening of clinical symptoms.
Tiagabine appears not to be efficacious in the treatment of acute mania.
TLDR
The results from this open trial suggest that tiagabine seems to have no pronounced antimanic efficacy compared with standard treatments such as valproate, lithium, or neuroleptics, and it also appears that rapid dosage increases for antimanics treatment can cause potentially severe side effects.
A Pilot Study of Mood in Epilepsy Patients Treated with Vagus Nerve Stimulation
TLDR
VNS treatment is associated with mood improvement as measured by multiple scales, but differences in mood scale scores over time between the VNS and a comparison group were not found, suggesting dissociation between seizure frequency reduction and mood change.
...
...