Psychotropic drugs affect Ser9-phosphorylated GSK-3 beta protein levels in rodent frontal cortex.

@article{Kozlovsky2006PsychotropicDA,
  title={Psychotropic drugs affect Ser9-phosphorylated GSK-3 beta protein levels in rodent frontal cortex.},
  author={Nitsan Kozlovsky and Shirly Amar and Robert Haim Belmaker and Galila Agam},
  journal={The international journal of neuropsychopharmacology},
  year={2006},
  volume={9 3},
  pages={337-42}
}
Glycogen synthase kinase (GSK)-3beta, a serine/threonine kinase highly abundant in brain is a negative regulator of signal transduction cascades including the phosphatidylinositol-3-kinase (PI3-K)/Akt and the Wnt. GSK-3beta has recently been suggested to be an intracellular target of the mood stabilizers lithium and valproate and of the typical and atypical antipsychotic agents haloperidol and clozapine. We have previously shown that these agents do not alter frontal cortex GSK-3beta protein… CONTINUE READING
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