Psychotropic drug influences on brain acetylcholine utilization

@article{Domino1972PsychotropicDI,
  title={Psychotropic drug influences on brain acetylcholine utilization},
  author={Edward F. Domino and Ann Elizabeth Wilson},
  journal={Psychopharmacologia},
  year={1972},
  volume={25},
  pages={291-298}
}
The cholinergic antisynthesis agent HC-3 was given intraventricularly to young male rats 20–30 days old to deplete brain acetylcholine (ACh). The rate of HC-3 induced depletion of ACh was used as an index of ACh utilization. Total brain ACh was determined following various doses of chlordiazepoxide, pentobarbital, chlorpromazine, methotrimeprazine, imipramine, morphine, d-amphetamine, scopolamine, LSD-25, and phencyclidine given i.p. alone and after intraventricular administration of HC-3. It… CONTINUE READING

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