Psychotropic Activity of New Fluorinated Derivatives of Tetrahydrocarbasoles

  title={Psychotropic Activity of New Fluorinated Derivatives of Tetrahydrocarbasoles},
  author={N. S. Nikolaeva and Vladimir B. Sokolov and Alexey Yu. Aksinenko and Ruslan K. Ovchinnikov and Sergey Bachurin and A. S. Kinzirskii},
  journal={Bulletin of Experimental Biology and Medicine},
Psychotropic properties of CA-7043× and CA-7050×, new fluorinated derivatives of tetrahydrocarbasoles, were examined on outbred CD1 mice and transgenic 5×FAD mice with Alzheimer disease. Both agents exerted cognitive-stimulating and anxiolytic effects in a dose of 5 mg/kg. In the new cage test, they retarded extinction of orientation and exploratory behavior. CA-7043× produced an anxiolytic effect on CD1 mice assessed in the open-field test and exerted cognitive-stimulating action in the new… CONTINUE READING