Psychotic symptoms in children and adolescents with 22q11.2 deletion syndrome: Neuropsychological and behavioral implications

@article{Debban2006PsychoticSI,
  title={Psychotic symptoms in children and adolescents with 22q11.2 deletion syndrome: Neuropsychological and behavioral implications},
  author={Martin Debban{\'e} and Bronwyn Glaser and Melissa David and Carl Feinstein and Stephan Eliez},
  journal={Schizophrenia Research},
  year={2006},
  volume={84},
  pages={187-193}
}
Individuals with 22q11.2 deletion syndrome (22q11DS) are at increased risk for developing schizophrenia: half of affected adolescents report transient psychotic experiences and up to 30% of adults are diagnosed with schizophrenia. Prospective studies have shown that psychotic symptoms in childhood are predictive of later schizophreniform disorders. The current study aimed to define the prevalence and correlates of psychotic symptoms (PS) in young children and adolescents with 22q11DS. Forty… Expand
Neurocognitive profile and onset of psychosis symptoms in children, adolescents and young adults with 22q11 deletion syndrome: A longitudinal study
TLDR
Results suggest neuropsychological deficits and depressive symptoms should be considered and monitored as possible clinical signs for the onset of psychosis in children, adolescents and young adults with 22q11DS. Expand
Why Are Children and Adolescents with 22 q 11 . 2 Deletion Syndrome at High Risk of Developing Schizophrenia ?
Because almost one-third of individuals affected by 22q11.2 deletion syndrome (22q11DS) develop schizophreniform disorders,1 the field of psychiatry and cognitive psychopathology has becomeExpand
Clinical and cognitive risk factors for psychotic symptoms in 22q11.2 deletion syndrome: a transversal and longitudinal approach
TLDR
Information on the characteristics and developmental trajectory of psychotic symptoms in patients at ultra-high risk for conversion to psychosis may ultimately help clinicians dealing with these patients to reduce the duration of untreated psychosis and improve outcome. Expand
Anxiety Disorders and Perceptual Disturbances in Adolescents with 22q11.2 Deletion Syndrome Treated with SSRI: A Case Series.
  • A. Stachon, Claire M. De Souza
  • Medicine
  • Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent
  • 2011
TLDR
Long-term follow-up, phenomenological and treatment efficacy studies in larger samples are needed to determine optimal treatment of psychotic symptoms in children and adolescents with 22qDS. Expand
Attenuated positive symptoms of psychosis in adolescents with chromosome 22q11.2 deletion syndrome
TLDR
Almost all presented with moderate to severe symptoms in the negative, disorganized, and general symptom domains of psychosis and clinical-high-risk syndromes in adolescents with 22q11.2DS. Expand
Psychosis in children with velocardiofacial syndrome (22q11.2 deletion syndrome)
TLDR
A 5-year follow-up study of 22qDS children who reported psychotic symptoms at baseline found they had an increased risk for a subsequent psychotic disorder, and a broad differential diagnosis should be considered when 22q DS children present with psychotic symptoms. Expand
Occurrence of affective disorders compared to other psychiatric disorders in children and adolescents with 22q11.2 deletion syndrome.
TLDR
The elevated occurrence of depressive, anxiety, and attention disorders in children with 22q DS, compared to community-based rates in children without 22qDS, suggest that psychiatric screening is needed. Expand
Psychiatric disorders and intellectual functioning throughout development in velocardiofacial (22q11.2 deletion) syndrome.
  • T. Green, D. Gothelf, +5 authors S. Eliez
  • Psychology, Medicine
  • Journal of the American Academy of Child and Adolescent Psychiatry
  • 2009
TLDR
The VIQ scores are negatively associated with age and rates of mood, and psychotic disorders increase dramatically during young adulthood, and neuropsychiatric deficits in individuals with VCFS seem to follow a developmental pattern. Expand
Predominant negative symptoms in 22q11.2 deletion syndrome and their associations with cognitive functioning and functional outcome.
TLDR
The present results indicate that one third of adolescents and young adults with 22q11.2DS display PNS, a pattern of symptoms associated with specific cognitive deficits and decreased functional outcome associated with distinct patterns of psychotic symptoms. Expand
Adolescents at ultra-high risk for psychosis with and without 22q11 deletion syndrome: A comparison of prodromal psychotic symptoms and general functioning
TLDR
The UHR+22q11DS have a specific clinical pattern characterized by higher negative symptoms, lower general functioning and an older age of onset of the UHR state, which may be of clinical value for the development of specific therapeutic intervention for UHR+, and of theoretical value since the two groups may share only some underlying etiopathogenetic mechanisms. Expand
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