Psychotic illness in people with Prader Willi syndrome due to chromosome 15 maternal uniparental disomy

@article{Boer2002PsychoticII,
  title={Psychotic illness in people with Prader Willi syndrome due to chromosome 15 maternal uniparental disomy},
  author={H. Boer and A. Holland and J. Whittington and J. Butler and D. Clarke},
  journal={The Lancet},
  year={2002},
  volume={359},
  pages={135-136}
}
  • H. Boer, A. Holland, +2 authors D. Clarke
  • Published 2002
  • Medicine
  • The Lancet
  • In a population-based study of Prader Willi syndrome (PWS), we investigated the relation between genetic subtypes of the syndrome and psychiatric morbidity. Of 25 patients aged 18 years or older, seven (28%) had severe affective disorder with psychotic features, with a mean age of onset of 26 years (SD 5.9). The seven people affected, all aged 28 years or older, included all five with disomies of chromosome 15, one with a deletion in this chromosome, and one with an imprinting centre mutation… CONTINUE READING
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