Psychostimulants in Psychiatry

@article{Warneke1990PsychostimulantsIP,
  title={Psychostimulants in Psychiatry},
  author={Lorne B. Warneke},
  journal={The Canadian Journal of Psychiatry},
  year={1990},
  volume={35},
  pages={10 - 3}
}
  • L. Warneke
  • Published 1 February 1990
  • Psychology, Medicine
  • The Canadian Journal of Psychiatry
The use of the psychostimulants in psychiatry is reviewed. A brief historical perspective on dextroamphetamine is presented, and a brief review of the psychopharmacology of dextroamphetamine, methylphenidate and magnesium pemoline is given. The literature on the use of stimulants in the treatment of resistant depression, apathetic geriatric patients and patients medically ill with a secondary depression is summarized and two case histories given to illustrate the clinical usefulness of the… 

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References

SHOWING 1-10 OF 60 REFERENCES

The use of psychostimulants in general psychiatry. A reconsideration.

TLDR
Generally, the existing studies are old and inadequate, but there is some evidence to support the judicious use of psychostimulants in selected clinical instances of several adult psychiatric syndromes.

The stimulant challenge test in depression.

: The psychostimulants remain controversial agents for the diagnosis and treatment of depression. One promising area of investigation involves the use of a brief trial of a stimulant to predict

The stimulant challenge test in depression.

  • D. Goff
  • Psychology
    The Journal of clinical psychiatry
  • 1986
TLDR
The literature on the neuroendocrine responses to stimulant administration, direct stimulant effects on mood and activity, and stimulant neurotransmitter effects is summarized to further understanding of stimulant action in relation to affective disorders.

Intravenous methamphetamine, adjuvant to psychotherapy.

  • M. Straker
  • Psychology, Medicine
    The American journal of psychiatry
  • 1953
TLDR
The clinical results are ascribed to the stimulating properties of methamphetamine; the effect is an increase of ego strength and self-esteem, together with the stripping away of superficial ego defenses and the partial dissolution of the resistances.

Dextroamphetamine Response as a Possible Predictor of Improvement With Tricyclic Therapy in Depression

TLDR
The data tend to support the hypothesis that dextroamphetamine response may predict the therapeutic effects of tricyclic drugs in depressed patients and support the possible significance of alterations of norepinephrine and catecholamine metabolism in at least some forms of depressive illness.

Psychostimulant treatment of depressive disorders secondary to medical illness.

TLDR
Psychostimulants appear to be a therapeutic option in the medically ill depressed population and may be more rapidly effective with fewer side effects than tricyclic antidepressants.

Treatment of depression in the medically ill elderly with methylphenidate.

TLDR
The results suggest that psychostimulants deserve further evaluation as antidepressant agents in the geriatric population and methylphenidate's effectiveness as an antidepressant were consistent with the findings of other investigators.

Dr. Sabelli Replies

TLDR
Many clinicians still use methylphenidate as an early adjunct to the treatment of depression to give symptom relief during the time the tricyclics require to produce their positive effect.

CLINICAL OBSERVATIONS ON THE EFFECT OF BENZEDRINE SULFATE: A STUDY OF PATIENTS WITH STATES OF CHRONIC EXHAUSTION, DEPRESSION AND PSYCHONEUROSIS

TLDR
Benzedrine has been utilized particularly in the treatment of congestion of the nasal mucosa, in maintaining blood pressure during spinal anesthesia and in orthostatic hypotension, and for the relief of spasm affecting the gastro-intestinal tract.
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