Psychostimulants given in adolescence modulate their effects in adulthood using the open field and the wheel-running assays.

@article{Yang2010PsychostimulantsGI,
  title={Psychostimulants given in adolescence modulate their effects in adulthood using the open field and the wheel-running assays.},
  author={Pamela Yang and Alan C. Swann and Nachum Dafny},
  journal={Brain research bulletin},
  year={2010},
  volume={82 3-4},
  pages={208-17}
}
Acute and chronic methylphenidate (MPD) were given to adults treated with MPD only in adulthood (adult I) and to adults that had been treated repeatedly during adolescence and adulthood (adult II). Two locomotor activity assays, the open field and the running wheel, were used in a dose response experiment to assess whether methylphenidate (MPD) treatment during adolescence would affect responses to MPD in adulthood. Each experiment lasted 11 days as follows: saline control on experimental day 1… CONTINUE READING

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