Psychostimulant-induced attenuation of hyperactivity and prepulse inhibition deficits in Adcyap1-deficient mice.

@article{Tanaka2006PsychostimulantinducedAO,
  title={Psychostimulant-induced attenuation of hyperactivity and prepulse inhibition deficits in Adcyap1-deficient mice.},
  author={Kazuhiro Tanaka and Norihito Shintani and Hitoshi Hashimoto and Naofumi Kawagishi and Yukio Ago and Toshio Matsuda and Ryota Hashimoto and Hiroshi Kunugi and Akiko Yamamoto and Chihiro Kawaguchi and Takeshi Shimada and Akemichi Baba},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 19},
  pages={
          5091-7
        }
}
Psychostimulants, including amphetamine, act as antihyperkinetic agents in humans with hyperkinetic disorder such as attention-deficit hyperactivity disorder and are known to be effective in enhancing attention-related processes; however, the underlying mechanisms have not been adequately addressed. Mice lacking the Adcyap1 gene encoding the neuropeptide pituitary adenylate cyclase-activating polypeptide (Adcyap1(-/-)) display psychomotor abnormalities, including increased novelty-seeking… CONTINUE READING

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