Psychosis in neurodegenerative disorders: recent developments

  title={Psychosis in neurodegenerative disorders: recent developments},
  author={W. Karameh and Geetanjali Murari and Tom A. Schweizer and David G Munoz and Corinne E. Fischer},
  journal={Current Opinion in Psychiatry},
Purpose of review This review presents the latest developments covered in the literature regarding psychosis in neurodegenerative disorders and discusses possible future research directions. Recent findings Recent findings in the field of psychosis and neurodegenerative disorders revolve around four main themes. The first theme is the impact of sex on the expression of psychosis in neurodegenerative disorders. The second theme focuses on the relationship between psychosis and neurodegenerative… 
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Current Limitations and Candidate Potential of 5-HT7 Receptor Antagonism in Psychiatric Pharmacotherapy
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Psychosis and dementia: risk factor, prodrome, or cause?
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Risk factors for early psychosis in PD: insights from the Parkinson's Progression Markers Initiative
Comparing baseline cognitive, biomarker and other PD psychosis risk factor data in patients who go on to develop illusions or hallucinations within 3–4 years of follow-up in the Parkinson's Progression Markers Initiative cohort of newly diagnosed PD suggests early onset illusions and formed hallucinations are linked to amyloid pathology in PD.
Gender and Pathology-Specific Effect of Apolipoprotein E Genotype on Psychosis in Alzheimer's Disease.
The APOE ε4 allele has a female-specific effect in inducing psychosis in AD through the formation of Lewy bodies, which was gender-specific, only reaching significance in females.
Neuroimaging Findings Related to Behavioral Disturbances in Alzheimer's Disease: A Systematic Review.
Results suggest that structural and functional changes in fronto-limbic areas may lead to emotional deregulation and symptom unawareness in Alzheimer's Disease.
Synaptic Proteome Compensation and Resilience to Psychosis in Alzheimer's Disease.
Accumulation of synaptic proteins, particularly those that are enriched in the postsynaptic density, is associated with resilience to psychosis in Alzheimer's disease.
The Role of Cerebrovascular Disease on Cognitive and Functional Status and Psychosis in Severe Alzheimer’s Disease
The association between hypertension and diabetes on psychosis is confirmed, specifically in delusions and the co-occurrence of delusions and hallucinations, and vascular lesions are not the mechanism through which vascular risk factors mediate psychosis.
Deconstructing psychosis and misperception symptoms in Parkinson’s disease
It is suggested that combined damage to the upper brainstem/thalamus and the posterior neocortex underlies both minor hallucinations/illusions and visual hallucinations and that the former pathology is more associated with visual hallucinations/frank psychosis and the latter is moreassociated with minor hallucinations-illusions.
Incident Psychosis in Subjects With Mild Cognitive Impairment or Alzheimer's Disease.
Estimating which subjects are at high risk for psychosis and the poor outcomes associated with it can help with family education and support decisions to implement nonpharmacologic strategies that may reduce or prevent symptoms.
Genetic Risk for Schizophrenia and Psychosis in Alzheimer Disease
These findings provide the first clear demonstration that AD+P is associated with common genetic variation and provide an unbiased link between polygenic risk for schizophrenia and a lower risk of psychosis in AD.