Psychosis in advanced Parkinson's disease
@article{Zoldan1995PsychosisIA, title={Psychosis in advanced Parkinson's disease}, author={J. Zoldan and G. Friedberg and M. Livneh and E. Melamed}, journal={Neurology}, year={1995}, volume={45}, pages={1305 - 1308} }
Psychosis, linked to chronic levodopa and other antiparkinsonian drug treatments, is a common and incapacitating complication of advanced Parkinson's disease (PD). The psychosis may be due, in part, to overstimulation of central serotonergic (5-HT) receptors. We treated 16 PD patients who had psychosis of 6 to 60 months' duration with the 5-HT3 receptor antagonist ondansetron (12 to 24 mg daily) in an open-label, short-term (4 to 8 weeks) trial. There was marked to moderate improvement (p < 0… CONTINUE READING
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