• DOI:10.1212/WNL.45.7.1305
Corpus ID: 45540572

Psychosis in advanced Parkinson's disease

@article{Zoldan1995PsychosisIA,
  title={Psychosis in advanced Parkinson's disease},
  author={J. Zoldan and G. Friedberg and M. Livneh and E. Melamed},
  journal={Neurology},
  year={1995},
  volume={45},
  pages={1305 - 1308}
}

J. Zoldan, G. Friedberg, +1 author E. Melamed

Published 1995

Medicine

Neurology

Psychosis, linked to chronic levodopa and other antiparkinsonian drug treatments, is a common and incapacitating complication of advanced Parkinson's disease (PD). The psychosis may be due, in part, to overstimulation of central serotonergic (5-HT) receptors. We treated 16 PD patients who had psychosis of 6 to 60 months' duration with the 5-HT3 receptor antagonist ondansetron (12 to 24 mg daily) in an open-label, short-term (4 to 8 weeks) trial. There was marked to moderate improvement (p < 0… CONTINUE READING

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