Psychoproteomic analysis of rat cortex following acute methamphetamine exposure.

  title={Psychoproteomic analysis of rat cortex following acute methamphetamine exposure.},
  author={Firas H. Kobeissy and Matthew W. Warren and A. K. Ottens and Shankar Sadasivan and Zhiqun Zhang and Mark S. Gold and Kevin K. W. Wang},
  journal={Journal of proteome research},
  volume={7 5},
Methamphetamine (METH) is recognized as one of the most abused psychostimulants in the United States. METH is an illicit drug that is known to exert neurotoxic effects on both dopaminergic and serotonergic neural systems both in vivo and in vitro. Our laboratory and others have been studying the biochemical mechanisms underlying METH-induced neurotoxicity. Here, we applied a novel psychoproteomic approach to evaluate METH-induced neurotoxicity following acute METH administration (4x10 mg/kg, ip… CONTINUE READING


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