Psychopharmacology of the endocannabinoids: far beyond anandamide

@article{Pamplona2012PsychopharmacologyOT,
  title={Psychopharmacology of the endocannabinoids: far beyond anandamide},
  author={Fabr{\'i}cio Alano Pamplona and Reinaldo Naoto Takahashi},
  journal={Journal of Psychopharmacology},
  year={2012},
  volume={26},
  pages={22 - 7}
}
The study of endocannabinoid pharmacology has proceeded from the discovery of Δ9-tetrahydrocannabinol, the main psychoactive compound in Cannabis sativa, to the identification of an endogenous endocannabinoid system that is essential for physiological modulation of neuronal functions. We have not yet achieved a complete understanding of the various roles of the endocannabinoids, but this is one of the fastest-growing fields in psychopharmacology. This review starts with a brief historical… 
View on SAGE
ncbi.nlm.nih.gov
40 Citations
Highly Influential Citations
2
Background Citations
16

Figures and Tables from this paper

40 Citations

Citation Type

Citation Type

Endocannabinoid System and Psychiatry: In Search of a Neurobiological Basis for Detrimental and Potential Therapeutic Effects
TLDR
The eCB system plays a critical role in psychiatry; however, detrimental consequences of manipulating this endogenous system cannot be underestimated over the potential and promising perspectives of its therapeutic manipulation.
Cannabinoids and zebrafish
TLDR
It is concluded that cannabinoids have behavioural effects in zebrafish that are comparable to some of those reported in the literature for mammals, in particular, the acute exposure response resembles behavioural effects reported for adult.
The endocannabinoid system and emotional processing: pathophysiology and therapeutic potential
TLDR
The contribution of the endocannabinoid system to the cardiovascular response to stress is explored, largely mediated by activation of the sympathetic nervous system and dependent on the activation of glucocorticoid receptors.
Effects of compounds that interfere with the endocannabinoid system on behaviors predictive of anxiolytic and panicolytic activities in the elevated T-maze
Cannabis, a complex plant: different compounds and different effects on individuals
  • Z. Atakan
  • Biology
    Therapeutic advances in psychopharmacology
  • 2012
TLDR
An overview of the biochemical basis of cannabis research is provided by examining the different effects of the two main compounds of the plant and the endocannabinoid system, and available information on the possible factors explaining variation of its effects upon different individuals is reviewed.
Neuronal populations mediating the effects of endocannabinoids on stress and emotionality
Cannabidiol (CBD) in Cancer Management
TLDR
Evidence of its efficacy in the integrative management of cancer including the side effects associated with its treatment is demonstrated, demonstrating its potential for integration with orthodox cancer care.
Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor
TLDR
It is shown that the anti-inflammatory lipid lipoxin A4 is an endogenous allosteric enhancer of the CB1 cannabinoid receptor, and displayed a CB1 receptor-dependent protective effect against β-amyloid (1–40)-induced spatial memory impairment in mice.
Cannabinoid receptors and cholecystokinin in feeding inhibition.
Epigenetic Regulation of Cannabinoid-Mediated Attenuation of Inflammation and Its Impact on the Use of Cannabinoids to Treat Autoimmune Diseases
TLDR
This review highlights how the epigenetic modulations caused by cannabinoids lead to the suppression of inflammation and helps identify novel pathways that can be used to target autoimmune diseases.
...
1
2
3
4
...

References

SHOWING 1-10 OF 172 REFERENCES
A brief history of cannabinoid and endocannabinoid pharmacology as inspired by the work of British scientists.
Molecular characterization of a peripheral receptor for cannabinoids
TLDR
The cloning of a receptor for cannabinoids is reported that is not expressed in the brain but rather in macrophages in the marginal zone of spleen, which helps clarify the non-psychoactive effects of cannabinoids.
Biochemistry and pharmacology of endovanilloids.
Oxidative metabolism of endocannabinoids.
  • K. Kozak, L. Marnett
  • Biology, Medicine
    Prostaglandins, leukotrienes, and essential fatty acids
  • 2002
There is increasing evidence that endocannabinoids play roles in a number of physiological and pathological processes ranging from the regulation of food intake to the inhibition of cancer cell…
The endocannabinoid signalling system: Biochemical aspects
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
TLDR
A comprehensive overview on the current state of knowledge of the endocannabinoid system as a target of pharmacotherapy is provided.
Cannabinoid receptors and endocannabinoids: Evidence for new players
TLDR
Evidence is reviewed suggesting that cannabinoids can modulate synaptic transmission, the cardiovascular system, and the immune system through receptors distinct from CB1 and CB2, and that an additional “independent” endocannabinoid signaling system that involves palmitoylethanolamide may exist.
Plant, synthetic, and endogenous cannabinoids in medicine.
TLDR
Cannabis and its best-known pharmacologically active constituents, the cannabinoids, became a protagonist in medical research only recently and opened new therapeutic possibilities through the modulation of the activity of cannabinoid receptors by targeting the biochemical mechanisms controlling endocannabinoid tissue levels.
The complications of promiscuity: endocannabinoid action and metabolism
TLDR
The complexity of the endocannabinoid system is highlighted, based on the promiscuous nature of ECLs and their metabolites, as well as the synthetic modulators of the Endocannabinoids system.
The expanding field of cannabimimetic and related lipid mediators
TLDR
This review explores the growing diversity of recently discovered putative lipid mediators and their relationship to the endogenous cannabinoid system and suggests the existence of a large and complex family of lipid mediator about which only little is known at this time.
...
1
2
3
4
5
...