Psychopharmacology of imipramine and desipramine: A comparative study of their effects in normal males

  title={Psychopharmacology of imipramine and desipramine: A comparative study of their effects in normal males},
  author={Alberto Di Mascio and George R. Heninger and Gerald L. Klerman},
The effects of imipramine and desipramine were each examined at three dose levels in normal males. A placebo-controlled, double-blind procedure was employed. Effects were measured in a variety of behavioral and subjective responses. The resulting drug-action profiles reveal that imipramine produced hypnotic-like actions, as evidenced by the observation — and subjective reports — of marked sleepiness and concomitant impairment of intelectual and visuo-motor functioning. Side-effects of a… CONTINUE READING

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