Psychopharmacology of imipramine and desipramine: A comparative study of their effects in normal males

@article{Mascio1964PsychopharmacologyOI,
  title={Psychopharmacology of imipramine and desipramine: A comparative study of their effects in normal males},
  author={Alberto Di Mascio and George R. Heninger and Gerald L. Klerman},
  journal={Psychopharmacologia},
  year={1964},
  volume={5},
  pages={361-371}
}
The effects of imipramine and desipramine were each examined at three dose levels in normal males. A placebo-controlled, double-blind procedure was employed. Effects were measured in a variety of behavioral and subjective responses. The resulting drug-action profiles reveal that imipramine produced hypnotic-like actions, as evidenced by the observation — and subjective reports — of marked sleepiness and concomitant impairment of intelectual and visuo-motor functioning. Side-effects of a… CONTINUE READING

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KLERMAN : The psychopharmacology of phenothiazine compounds : A comparative study of the effects of ehlorpromazine , promethazine , trifluoperazine , and perphenazine in normal males

  • W. U.
  • J . nerv . ment . Dis . I
  • 1963

BttODIE: On the mechanism of antidepressant action of imipramine-like drugs

  • SULSER, J. WATTS, B B.
  • Ann. N.Y. Acad. Sci. 96,
  • 1962

Clinical trial with desmethylimipramine , a new antidepressant compound

  • W. POLDINGER
  • Canad . med . Ass . J .
  • 1962

Desmethylimipramine in the treatment of depression: Pilot study in a general hospital and outpatient setting

  • A. MArN
  • Canad. reed. Ass. J
  • 1962

BREL: (N(-Methylaminopropyl) Iminodibenzyl: A new antidepressant

  • L. MEUgA, L. G. ABOOD, H J.
  • J. Neuropsychiat
  • 1961

SEIFTER: Possible model of antidepressive action of imipramine

  • L. STIN
  • Science
  • 1961

SIGG: The potentiation of methylphenidate by imipramine, amitriptyline and their desmethyl analogues

  • R. T. HILL, I. KOOSIS, M. W. MINOR, B E.
  • Pharmacologist 3,
  • 1961

Die Beeinflussung der Reiziibertragung im peripheren Sympathicus dureh Tofranil

  • U. ScAPPI
  • Helv. physiol, pharmacol. Acta
  • 1960

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