Psychopharmacological interventions in autism spectrum disorder

  title={Psychopharmacological interventions in autism spectrum disorder},
  author={Robert E. Accordino and Christen L. Kidd and Laura C. Politte and Charles A Henry and Christopher J. McDougle},
  journal={Expert Opinion on Pharmacotherapy},
  pages={937 - 952}
ABSTRACT Introduction: Individuals with autism spectrum disorder (ASD) commonly present for treatment of emotional and behavioral disturbances associated with ASD’s “core” symptoms. Psychotropic medications are widely utilized in alleviating associated emotional and behavioral symptoms. Areas covered: Emotional and behavioral disturbances associated with ASD include irritability/severely disruptive behavior, which comprises the heaviest symptom burden; hyperactivity and other Attention-Deficit… 

Autism Spectrum Disorder: a Review of Behavioral and Psychiatric Challenges Across the Lifespan

There is an increasing emphasis on the development of interventions and services that are effective in ASD over the lifespan, with a growing number of evidence-based treatments and interventions for autism-related challenges and for the treatment of behavioral and psychiatric disorders in autistic individuals.

Assessment and Treatment of Anxiety in Youth With Autism Spectrum Disorders

Assessment and treatment of clinical anxiety in youth with autism spectrum disorder require a standardized approach to improve outcomes for youth with ASD, and psychoeducation, coordination of care, and modified cognitive-behavioral therapy are recommended.

[Diagnosis and Therapeutic Interventions in Autism Spectrum Disorders in Adulthood].

Besides psychoeducation on ASD and its frequently associated comorbidities, psychotherapy for adults with ASD should focus on the training and development of social-communicative skills.

Growing Up with Autism: Incorporating Behavioral Management and Medication to Manage Self-Injurious Behavior

Autism spectrum disorder (ASD) is often complicated by psychiatric and medical comorbidities such as intellectual disability, epilepsy, anxiety, mood disorders, sleep issues, and gastrointestinal

Concomitant medication use in children with autism spectrum disorder: Data from the Autism Biomarkers Consortium for Clinical Trials.

The findings suggest that exclusion of children taking concomitant psychotropic medications in trials could limit the clinical representativeness of the study population, perhaps even excluding children who may most benefit from new treatment options.

N-acetylcysteine may reduce repetitive behaviors in children with autism: a case series

NAC adjunction to risperidone treatment may be helpful to reduce repetitive behaviors in children with ASD with limited adverse effects and good tolerability.

The effect of autistic traits on response to and side-effects of pharmacological ADHD treatment in children with ADHD: results from a prospective clinical cohort

The results did not implicate that ADHD patients with concomitant ASD symptoms have decreased treatment effect of ADHD medication than patients with ADHD without concomant ASD symptoms, and did not support that ADHD Patients with ASD symptoms experienced significantly more side-effects than ADHD patients without ASD symptoms.

Lurasidone an Effective Alternative for the Treatment of Irritability Associated With Autism Spectrum Disorder

Lurasidone was an effective alternative due to its unique psychopharmacologic profile and it was well tolerated without any side effects, and its efficacy was more observed at higher doses.

Atypical Antipsychotics for Irritability in Pediatric Autism: A Systematic Review and Network Meta-Analysis.

Risperidone and aripiprazole were the two best drugs, with comparable efficacy and safety in pediatric ASD patients, and these two medications could be beneficial in improving irritability in these patients.

Pharmacologic treatment of obsessive-compulsive disorder comorbidity

This paper summarized the available data on the treatment of the main OCD comorbidities and identified the homogenous subgroup, subtyping patients according to comor bidity patterns, symptom dimensions, clinical course, neurocognitive and neurophysiological dysfunctions.



Preliminary investigation of lithium for mood disorder symptoms in children and adolescents with autism spectrum disorder.

This preliminary assessment of lithium in children and adolescents with ASD suggests that lithium may be a medication of interest for those who exhibit two or more mood disorder symptoms, particularly mania or euphoria/elevated mood.

Use of Psychotropic Medication in Children and Adolescents With Autism Spectrum Disorders

A parent report of comorbid diagnosis of attention-deficit/hyperactivity disorder, bipolar disorder, obsessive-compulsive disorder, depression, or anxiety was associated with a high rate of use, with 80% receiving ≥1 psychotropic medication.

Divalproex sodium vs. placebo in the treatment of repetitive behaviours in autism spectrum disorder.

Preliminary support for the use of divalproex in treating repetitive behaviours in ASD is provided, although further research is needed to evaluate the specificity and mechanism of action of these findings.

Risperidone in children with autism and serious behavioral problems.

Risperidone was effective and well tolerated for the treatment of tantrums, aggression, or self-injurious behavior in children with autistic disorder and the benefit was maintained at six months.

Genetics of childhood disorders: XLIV. autism, part 3: psychopharmacology of autism.

  • C. McDougleD. Posey
  • Psychology, Medicine
    Journal of the American Academy of Child and Adolescent Psychiatry
  • 2002
The pharmacological management of hyperactivity and impaired attention has proven particularly challenging and lithium, valproic acid, carbamazepine, and gabapentin, have not been reported in well-defined groups of autistic subjects.

Efficacy of Methylphenidate Among Children with Autism and Symptoms of Attention-Deficit Hyperactivity Disorder

Results suggest that methylphenidate can be efficacious for children with autism and ADHD symptoms, however, this group of children seems to be particularly susceptible to adverse side effects.

Risperidone in the Treatment of Disruptive Behavioral Symptoms in Children With Autistic and Other Pervasive Developmental Disorders

Risperidone was well tolerated and efficacious in treating behavioral symptoms associated with PDD in children and seemed manageable with dose/dose-schedule modification.

Use of clonidine in children with autism spectrum disorders

Long-term oxytocin administration improves social behaviors in a girl with autistic disorder

This case is the first to illustrate long-term administration of oxytocin nasal spray in the targeted treatment of social impairments in a female with autistic disorder and suggests that long- term nasal oxytocIn spray is promising and well-tolerated for treatment ofSocial impairments of patients with ASDs.

Memantine as Adjunctive Therapy in Children Diagnosed With Autistic Spectrum Disorders: An Observation of Initial Clinical Response and Maintenance Tolerability

Autism and Pervasive Developmental Disorder Not Otherwise Specified are common developmental problems often seen by child neurologists. There are currently no cures for these lifelong and socially