Psychopharmacological effects of melatonin in mouse and rat.

  title={Psychopharmacological effects of melatonin in mouse and rat.},
  author={David Sugden},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={227 3},
  • David Sugden
  • Published 1983 in
    The Journal of pharmacology and experimental…
Some of the psychopharmacological characteristics of melatonin have been defined using a number of established tests of sedative/hypnotic, anticonvulsant and analgesic activity in mice and rats. The effect of melatonin in these tests has been compared to its neurotoxicity and acute toxicity. In the mouse, a low dose of melatonin (20 mg/kg i.p.) potentiated pentobarbitone- and barbitone-induced sleep. Melatonin also potentiated pentobarbitone-induced sleep in the rat. Higher doses (greater than… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 39 extracted citations

Similar Papers

Loading similar papers…