Psychopharmacological effects in the radial-arm maze.

  title={Psychopharmacological effects in the radial-arm maze.},
  author={Edward D. Levin},
  journal={Neuroscience and biobehavioral reviews},
  volume={12 2},
The radial-arm maze (RAM) has become a very widely used method for assessing spatial memory in rodents. It has proven to be quite useful in the investigation of the effects of a variety of pharmacological manipulations on spatial memory. The cholinergic system has been found to be crucial for accurate RAM performance. Blockade of either muscarinic or nicotinic receptors impairs performance. Other transmitter systems such as dopamine and the opiates have also been found to be involved with the… CONTINUE READING

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