Psychopathology in great apes: Concepts, treatment options and possible homologies to human psychiatric disorders

  title={Psychopathology in great apes: Concepts, treatment options and possible homologies to human psychiatric disorders},
  author={Martin Br{\"u}ne and Ute Br{\"u}ne-Cohrs and William C. McGrew and Signe Preuschoft},
  journal={Neuroscience \& Biobehavioral Reviews},

Signs of Mood and Anxiety Disorders in Chimpanzees

Chimpanzees display behavioral clusters similar to PTSD and depression in their key diagnostic criteria, underscoring the importance of ethical considerations regarding the use of chimpanzees in experimentation and other captive settings.

Comparative Psychopathology: Connecting Comparative and Clinical Psychology

Present day psychologists apply what is known about maladaptive behavior and the factors that facilitate positive human behavior to improve the quality of life for non-human taxa living in captive settings to ameliorate aberrant behaviors.


This review aims to raise awareness among the veterinary community of the wealth of literature on NHP psychopathologies in human medicine and anthropology literature and calls for the necessity to include mental health assessments and professionally structured treatment approaches in NHP medicine.

Building an Inner Sanctuary: Complex PTSD in Chimpanzees

Analysis of case studies of chimpanzees in residence at a sanctuary concludes that a diagnosis of Complex PTSD in chimpanzees is consistent with descriptions of trauma-induced symptoms as described by the DSM-IV and human trauma research.

Behavioural Profiles in Captive-Bred Cynomolgus Macaques: Towards Monkey Models of Mental Disorders?

It is suggested that animals from the low n groups (D and E) present depressive-like and anxious-like symptoms, reminiscent of depressive and generalized anxiety disorders, and the use of unbiased behavioural observations might allow the identification of animal models of human mental/behavioural disorders and their most appropriate control groups.

Psychological Distress in Chimpanzees Rescued From Laboratories

This analysis qualitatively analyzed symptoms of psychological distress in a sample of 253 chimpanzees rescued from biomedical research now residing at an accredited chimpanzee sanctuary and includes an illustrative case study of one rescued chimpanzee who engages in self-injurious behaviors and meets modified Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria for posttraumatic stress disorder.

Rehabilitation of research chimpanzees: Stress and coping after long-term isolation

Stereotypic behavior in nonhuman primates as a model for the human condition.

  • C. Lutz
  • Psychology, Biology
    ILAR journal
  • 2014
Stereotypies that develop spontaneously in nonhuman primates can provide an effective model for repetitive stereotyped behavior in people with neurodevelopmental or obsessive-compulsive disorders and may serve as a better model for stereotyping behavior in individuals with autism or intellectual disability.



The effects of neonatal stress on brain development: Implications for psychopathology

An overview of the corticotropin-releasing-factor (CRF) system and its role as a mediator in the development of the stress response, major depression, and posttraumatic stress disorder is presented.

Psychobiology of Early Social Attachment in Rhesus Monkeys Clinical Implications

  • G. Kraemer
  • Psychology, Biology
    Annals of the New York Academy of Sciences
  • 1997
The long-standing effects of caregiver privation on behavior and emotionality are probably attributable to changes in multiple regulatory systems and cognitive-emotional integration rather than restricted effects on the activity of any specific set of neurochemical systems.

Toward an Integration of Interpersonal and Biological Processes: Evolutionary Psychiatry as an Empirically Testable Framework for Psychiatric Research

Empirical psychiatry is proposed as a meta-theory to integrate biological and interpersonal aspects of psychopathology to provide a functional classification which adds to the contemporary psychiatric nosology through analysis according to specific conflicts of adaptation, the pursuit of biosocial goals, and proximate specifiers such as genetic, developmental, and interpersonal causes of disorders.

Origins of Psychopathology: The Phylogenetic and Cultural Basis of Mental Illness

What are the origins of human psychopathology? Is mental illness a relatively recent phenomenon, or has it been with us throughout evolution? In Origins of Psychopathology, Horacio Fabrega Jr.

The concept of alternative strategies and its relevance to psychiatry and clinical psychology

  • A. Troisi
  • Psychology, Biology
    Neuroscience & Biobehavioral Reviews
  • 2005

Theory of mind—evolution, ontogeny, brain mechanisms and psychopathology

Stereotypy in monkeys and humans

If stereotypy is regarded as a consequence of failure to use sensory input to direct behaviour, therapeutic regimes designed to stimulate responsive behaviours and social interactions are more likely to be effective in the long run than direct attempts to suppress stereotypy.

Variables influencing the origins of diverse abnormal behaviors in a large sample of captive chimpanzees (Pan troglodytes)

The association of some abnormal behaviors with mother‐rearing suggests that some form of social learning may be involved in the origin of some of these behavior patterns.

A preliminary investigation of the construct of psychopathic personality (psychopathy) in chimpanzees (Pan troglodytes).

Findings suggest that the psychopathy construct may be relevant to chimpanzees, and further validation of the CPM is needed.