Psychopathological manifestations of joint hypermobility and joint hypermobility syndrome/ Ehlers–Danlos syndrome, hypermobility type: The link between connective tissue and psychological distress revised

@article{Sinibaldi2015PsychopathologicalMO,
  title={Psychopathological manifestations of joint hypermobility and joint hypermobility syndrome/ Ehlers–Danlos syndrome, hypermobility type: The link between connective tissue and psychological distress revised},
  author={Lorenzo Sinibaldi and Gianluca Ursini and Marco Castori},
  journal={American Journal of Medical Genetics Part C: Seminars in Medical Genetics},
  year={2015},
  volume={169},
  pages={106 - 97}
}
Psychological distress is a known feature of generalized joint hypermobility (gJHM), as well as of its most common syndromic presentation, namely Ehlers–Danlos syndrome, hypermobility type (a.k.a. joint hypermobility syndrome — JHS/EDS‐HT), and significantly contributes to the quality of life of affected individuals. Most published articles dealt with the link between gJHM (or JHS/EDS‐HT) and anxiety‐related conditions, and a novel generation of studies is emerging aimed at investigating the… 
Neurodevelopmental atypisms in the context of joint hypermobility, hypermobility spectrum disorders, and Ehlers–Danlos syndromes
  • C. Baeza-Velasco
  • Medicine
    American journal of medical genetics. Part C, Seminars in medical genetics
  • 2021
TLDR
This article reviews the pertinent literature concerning neurodevelopmental conditions for which there is some evidence of an association with JHM/HSD/EDS and underlying mechanism hypotheses for such interconnections are reviewed.
Hypermobile Ehlers–Danlos syndrome (a.k.a. Ehlers–Danlos syndrome Type III and Ehlers–Danlos syndrome hypermobility type): Clinical description and natural history
TLDR
The hypermobile type of Ehlers–Danlos syndrome is described largely in those with musculoskeletal complaints including joint hypermobility, joint subluxations/dislocations, as well as skin and soft tissue manifestations.
Cognitive, emotional, and behavioral considerations for chronic pain management in the Ehlers–Danlos syndrome hypermobility-type: a narrative review
TLDR
It is necessary to explore the psychosocial functioning of patients as part of the overall chronic pain management in the EDS hypermobility-type, especially when they do not respond to biomedical approaches as psychological factors may be operating against rehabilitation.
Contemporary approach to joint hypermobility and related disorders
TLDR
Asymptomatic, nonsyndromic joint Hypermobility, hypermobility spectrum disorders and EDS (particularly, the hypermobile type) are the most common phenotypes in children and adults with jointhypermobility.
Attention-deficit/hyperactivity disorder, joint hypermobility-related disorders and pain: expanding body-mind connections to the developmental age
TLDR
A map of the pathophysiological and psychopathological pathways connecting both conditions is proposed and may testify for the dyadic nature of mind-body connections during critical periods of post-natal development.
Joint Hypermobility Links Neurodivergence to Dysautonomia and Pain
TLDR
There is a strong link between the expression of joint hypermobility, dysautonomia, and pain, more so than in the comparison group and the number of hypermobile joints was found to mediate the relationship between neurodivergence and symptoms of both dysautonomic and pain.
Autism, Joint Hypermobility-Related Disorders and Pain
TLDR
Considering the high probability that pain remains disregarded and untreated in people with ASD due to communication and methodological difficulties, increasing awareness about the interconnection between ASD and hypermobility-related disorders is relevant, since it may help identify those ASD patients susceptible to chronic pain.
The Relationship Between Generalised Joint Hypermobility and Autism Spectrum Disorder in Adults: A Large, Cross-Sectional, Case Control Comparison
TLDR
ASD with GJH may represent a novel subgroup of ASD in terms of aetiopathology and clinical presentation and future research should elucidate the aetiological factors behind the association between ASD and GjH and evaluate how the comorbidity of GJh affects ASD outcomes.
Generalised joint hypermobility and neurodevelopmental traits in a non-clinical adult population
TLDR
Although GJH is overrepresented in clinical cases with neurodevelopmental disorders, such an association seems absent in a normal population, and this association is presumably limited to clinical populations.
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TLDR
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TLDR
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