Psychopathological and cognitive effects of therapeutic cannabinoids in multiple sclerosis: a double-blind, placebo controlled, crossover study.

@article{Aragona2009PsychopathologicalAC,
  title={Psychopathological and cognitive effects of therapeutic cannabinoids in multiple sclerosis: a double-blind, placebo controlled, crossover study.},
  author={Massimiliano Aragona and Emanuela Onesti and Valentina Tomassini and Antonella Conte and Shiva Gupta and Francesca Gilio and Patrizia Pantano and Carlo Pozzilli and Maurizio Inghilleri},
  journal={Clinical neuropharmacology},
  year={2009},
  volume={32 1},
  pages={41-7}
}
OBJECTIVES To study possible psychopathological symptoms and cognitive deficits, abuse induction, as well as general tolerability and effects on quality of life, fatigue and motor function in cannabis-naïve patients with multiple sclerosis (MS) treated with a free-dose cannabis plant extract (Sativex). METHODS In an 8-week, randomized, double-blind, placebo-controlled, parallel group crossover trial, 17 cannabis-naïve patients with MS were assessed at baseline and at the end of the cannabis… CONTINUE READING
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