Psychoneuroendocrinology of anorexia nervosa

@article{Sdersten2006PsychoneuroendocrinologyOA,
  title={Psychoneuroendocrinology of anorexia nervosa},
  author={Per S{\"o}dersten and Cecilia Bergh and Modjtaba Zandian},
  journal={Psychoneuroendocrinology},
  year={2006},
  volume={31},
  pages={1149-1153}
}
It is suggested that the symptoms of anorexia nervosa are physiological responses to starvation. There is no evidence of a neural or non-neural dysfunction that predisposes women for anorexia nervosa and the endocrine and psychological consequences of starvation are reversed once patients have re-learnt how to eat and regained a normal body weight. Because variability in the supply of food may be a common evolutionary condition, it is more likely that body weight is variable than constant in… Expand

Figures and Topics from this paper

Behavioral neuroendocrinology and treatment of anorexia nervosa
TLDR
It is suggested that the normal behavioral role of neuropeptide Y is to facilitate the search for food and switch attention from sexual stimuli to food in anorexia nervosa because neural mechanisms of reward and attention are engaged. Expand
Anorexie mentale, activité physique et nutrition : quelles potentialisations ?
TLDR
Care must take into account hyperactivity during AN with an approach including help to consciously acknowledge these symptoms and their character directly associated with the eating disorder, and this, in order for the patient and the care team to have as a common goal the progressive decrease of the PA's level. Expand
Verifying Feighner’s Hypothesis; Anorexia Nervosa Is Not a Psychiatric Disorder
TLDR
The results indicate that psychiatric diagnoses, which are reliable and valid in patients with psychiatric disorders, are less well suited for patients with anorexia, and support the alternative, clinically relevant hypothesis that the behavioral phenotype of the patients should be addressed directly. Expand
Towards a neurocircuitry in anorexia nervosa: evidence from functional neuroimaging studies.
TLDR
The role of the parietal cortex, anterior and subgenual cingulate cortex, frontal cortex and temporal lobe in light of the cardinal symptoms of anorexia nervosa is discussed. Expand
Perspectiva evolucionista de los trastornos de la conducta alimentaria
Background: Evolutionary theory has contributed with physiological, psychological and behavioral explanations to the comprehension and treatment of eating disorders (ED). The aim of this review is toExpand
Neuropeptide Y facilitates activity-based-anorexia
TLDR
The finding that treatment with NPY can increase physical activity and decrease food intake and cause a loss of body weight is in line with the clinical observation that patients with anorexia nervosa are physically hyperactive and eat only little food despite having depleted body fat and up-regulated hypothalamic "orexigenic" peptides. Expand
Serotonin transporter binding in eating disorders
TLDR
As the patients in that report showed increases in perfectionism and anxiety, some patients had even elevated levels of obsessive compulsive disorder, it cannot be excluded that the “divergent 5-HTT activity” that Bailer et al. (2007) reported is an epiphenomenon to these symptoms and unrelated to the eating disorder. Expand
Temporal relationships between awakening cortisol and psychosocial variables in inpatients with anorexia nervosa - A time series approach.
  • B. Wild, Tatjana Stadnitski, +6 authors H. Friederich
  • Psychology, Medicine
  • International journal of psychophysiology : official journal of the International Organization of Psychophysiology
  • 2016
TLDR
Higher cortisol values were temporally associated with higher values of depressive feelings in patients with anorexia nervosa, and patients with HSS appeared to show less stable awakening cortisol time series compared to patients with LSS. Expand
Assessing for Eating Disorders: A Primer for Gastroenterologists.
TLDR
The gastroenterology provider is in a unique position to identify, manage, and facilitate treatment for an eating disorder early in the course of the illness, as well as remain well versed in the identification of these diseases. Expand
Effective treatment of eating disorders: Results at multiple sites.
TLDR
The results of a study based on 1,428 patients with eating disorders treated at 6 clinics compare favorably with the poor long-term remission rates, the high rate of relapse, and the high mortality rate reported with standard treatments for eating disorders. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 38 REFERENCES
Neuroendocrine effects of citalopram infusion in anorexia nervosa
TLDR
It is demonstrated that serotonergic activation by citalopram affects corticotroph and lactotroph but not somatotroph secretion in anorexic as well as in normal subjects, while there seems to be an impairment of the adrenal function in this group of patients. Expand
The outcome of anorexia nervosa in the 20th century.
  • H. Steinhausen
  • Psychology, Medicine
  • The American journal of psychiatry
  • 2002
TLDR
There was no convincing evidence that the outcome of anorexia nervosa improved over the second half of the last century, and vomiting, bulimia, and purgative abuse, chronicity of illness, and obsessive-compulsive personality symptoms are unfavorable prognostic features. Expand
Understanding eating disorders
TLDR
A parsimonious, neurobiologically realistic explanation why eating disorders develop and why they are maintained is offered and it is suggested that the brain mechanisms of reward are activated when food intake is reduced and that disordered eating behavior is subsequently maintained by conditioning to the situations in which the disordered Eating behavior developed via the neural system for attention. Expand
Behavior, attitude, nutrition and endocrinology in anorexia nervosa: A LONGITUDINAL STUDY IN 24 PATIENTS
TLDR
The data suggest that the dysfunctions in anorexia nervosa patients in the hyporthalamo‐pituitary‐adrenal and ‐gonadal axis have little specificity for this disease and are mainly a consequence of nutritional factors and starvation. Expand
Randomized controlled trial of a treatment for anorexia and bulimia nervosa
TLDR
It is suggested that most patients treated with this method recover, because the risk of relapse is maximal in the first year after remission, and the estimated rate of remission was 75%, and estimated time to remission was 14.7 months. Expand
Abnormal hypothalamic-pituitary-adrenal function in anorexia nervosa. Pathophysiologic mechanisms in underweight and weight-corrected patients.
TLDR
In underweight anorexics, the pituitary responds appropriately to corticotropin-releasing hormone, being restrained in its response by the elevated levels of cortisol, which suggests that hypercortisolism in anorexia nervosa reflects a defect at or above the hypothalamus. Expand
Leptin and body weight regulation in patients with anorexia nervosa before and during weight recovery.
TLDR
Leptin contributes to metabolic adaptation in women with anorexia nervosa and is associated with weight gain, and changes in leptin secretion were associated with energy intake and REE. Expand
Body weight is regulated by the brain: a link between feeding and emotion
TLDR
This review focuses on the established brain machinery of food intake and body weight, especially on the melanocortin and neuropeptide Y (NPY) systems, which play a critical role in receiving and processing critical peripheral metabolic cues such as leptin and ghrelin. Expand
Fluoxetine after weight restoration in anorexia nervosa: a randomized controlled trial.
TLDR
This study failed to demonstrate any benefit from fluoxetine in the treatment of patients with anorexia nervosa following weight restoration and future efforts should focus on developing new models to understand the persistence of this illness and on exploring new psychological and pharmacological treatment approaches. Expand
Neuropeptide Y facilitates activity-based-anorexia
TLDR
The finding that treatment with NPY can increase physical activity and decrease food intake and cause a loss of body weight is in line with the clinical observation that patients with anorexia nervosa are physically hyperactive and eat only little food despite having depleted body fat and up-regulated hypothalamic "orexigenic" peptides. Expand
...
1
2
3
4
...