Psychomotor, respiratory and neuroendocrinological effects of buprenorphine and amitriptyline in healthy volunteers

  title={Psychomotor, respiratory and neuroendocrinological effects of buprenorphine and amitriptyline in healthy volunteers},
  author={Ulpu K Saarialho-Kere and Mauri J. Mattila and Markku P. J. Paloheimo and Timo T. Sepp{\"a}l{\"a}},
  journal={European Journal of Clinical Pharmacology},
Actions and interactions of buprenorphine (BUP) and amitriptyline (AMI) on performance and respiration were studied double-blind and cross-over in 12 healthy volunteers. After one-week pretreatments with AMI or placebo, the subjects received on Day 8 placebo, BUP or AMI so that the final treatments were 1) placebo, 2) acute AMI 50 mg, 3) acute BUP, 4) subchronic AMI + acute BUP and 5) subchronic AMI. The subacute treatments were started at two-week intervals. A Mapleson D rebreathing circuit… CONTINUE READING
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