Psychological stress induces chemoresistance in breast cancer by upregulating mdr1.

  title={Psychological stress induces chemoresistance in breast cancer by upregulating mdr1.},
  author={Fengxi Su and Nengyong Ouyang and Pengcheng Zhu and Nengtai Ouyang and Weijuan Jia and Chang Gong and Xuexia Ma and Huanbin Xu and Erwei Song},
  journal={Biochemical and biophysical research communications},
  volume={329 3},
Psychological distress reduces the efficacy of chemotherapy in breast cancer patients. The mechanism may be related to the altered neuronal or hormonal secretions during stress. Here, we reported that adrenaline, a hormone mediating the biological activities of stress, upregulates mdr1 gene expression in MCF-7 breast cancer cells via alpha(2)-adrenergic receptors in a dose-dependent manner. Mdr1 upregulation can be specifically inhibited by pretreatment with mdr1-siRNA. Consequently, adrenergic… CONTINUE READING
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