Psychological stress-induced accelerated colonic transit in rats involves hypothalamic corticotropin-releasing factor.

@article{Mnnikes1993PsychologicalSA,
  title={Psychological stress-induced accelerated colonic transit in rats involves hypothalamic corticotropin-releasing factor.},
  author={Hubert M{\"o}nnikes and B M Schmidt and Yvette F. Tach{\'e}},
  journal={Gastroenterology},
  year={1993},
  volume={104 3},
  pages={716-23}
}
BACKGROUND Brain corticotropin-releasing factor (CRF) is involved in stress-induced accelerated colonic transit. Brain sites of action of CRF to stimulate colonic transit were investigated in conscious fed rats. METHODS Bilateral guide cannulae were chronically implanted into the paraventricular nucleus of the hypothalamus (PVN) or central amygdala for peptide microinjection and a catheter into the proximal colon to measure colonic transit. RESULTS CRF (0.6 nmol/rat) injected into the PVN… CONTINUE READING

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