Psychological stress and susceptibility to the common cold.

@article{Cohen1991PsychologicalSA,
  title={Psychological stress and susceptibility to the common cold.},
  author={Sheldon Cohen and David A. J. Tyrrell and A P Smith},
  journal={The New England journal of medicine},
  year={1991},
  volume={325 9},
  pages={606-12}
}
BACKGROUND It is not known whether psychological stress suppresses host resistance to infection. To investigate this issue, we prospectively studied the relation between psychological stress and the frequency of documented clinical colds among subjects intentionally exposed to respiratory viruses. METHODS After completing questionnaires assessing degrees of psychological stress, 394 healthy subjects were given nasal drops containing one of five respiratory viruses (rhinovirus type 2, 9, or 14… CONTINUE READING
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