Psychological and neural mechanisms of the affective dimension of pain.

@article{Price2000PsychologicalAN,
  title={Psychological and neural mechanisms of the affective dimension of pain.},
  author={Donald D. Price},
  journal={Science},
  year={2000},
  volume={288 5472},
  pages={
          1769-72
        }
}
  • D. Price
  • Published 9 June 2000
  • Psychology, Biology
  • Science
The affective dimension of pain is made up of feelings of unpleasantness and emotions associated with future implications, termed secondary affect. Experimental and clinical studies show serial interactions between pain sensation intensity, pain unpleasantness, and secondary affect. These pain dimensions and their interactions relate to a central network of brain structures that processes nociceptive information both in parallel and in series. Spinal pathways to limbic structures and medial… 

Forebrain pain mechanisms

Plasticity in brain processing and modulation of pain.

Hippocampal Mechanisms Linking Chronic Pain and Depression

ABSTRACTThe emotional or affective component of pain regulates mood; it occurs primarily in the brain's limbic system; and a negative impact on affect is required in order for stimulus to be

A new perspective on the anterior cingulate cortex and affective pain

Cerebral and spinal modulation of pain by emotions

Functional cerebral imaging and psychophysiological methods combined with connectivity analyses suggested an involvement of prefrontal, parahippocampal, and brainstem structures in the cerebral and cerebrospinal modulation of pain by emotions.

Neuroscience of Pain and Emotion

The neural mechanisms of pain-related affect and memory

Abstract The pain experience includes a sensory-discriminative and an emotional components. The affective dimension refers to the unpleasantness or aversion of sensation. The great progress at the

The Neurobiology of Pain, Affect and Hypnosis

  • J. Feldman
  • Psychology
    The American journal of clinical hypnosis
  • 2004
Reviewing studies that delineate the overlapping brain circuits involved in the processing of pain and emotions, it is proposed that the activation of a portion of the prefrontal cortex in response to both hypnotic suggestions for decreased pain and to positive emotional experience might indicate a more general underlying mechanism.

Behavioral therapy: emotion and pain, a common anatomical background

Nonpharmacological therapies, such as cognitive behavioral therapy, yoga, biofeedback, and meditation, that are often used for enhancing emotional regulation, are increasingly being turned to for augmenting management of migraine and pain.

Cerebral cortex modulation of pain

An extensive cortical network associated with pain processing has been revealed using multiple methods over the past decades, and multiple neurotransmitters are involved in the modulation of pain by these cerebral cortical structures.
...

References

SHOWING 1-10 OF 38 REFERENCES

Region‐specific encoding of sensory and affective components of pain in the human brain: A positron emission tomography correlation analysis

The results of the activation study indicate that different functions in pain processing can be attributed to different brain regions.

Pain intensity processing within the human brain: a bilateral, distributed mechanism.

Results confirm the existence of a highly distributed, bilateral supraspinal mechanism engaged in the processing of pain intensity and conserve pain intensity information across multiple, functionally distinct brain areas.

Pain perception: is there a role for primary somatosensory cortex?

The bulk of the evidence now strongly supports a prominent and highly modulated role for S1 cortex in the sensory aspects of pain, including localization and discrimination of pain intensity.

A psychophysical comparison of sensory and affective responses to four modalities of experimental pain.

It is observed that, relative to the perceived intensity of the individual stimuli, subjects consistently differentiate among the degrees of unpleasantness evoked by the four stimulus modalities, and contact heat stimuli may be ideally suited for assessing sensory-discriminative aspects of pain perception.

Pain affect encoded in human anterior cingulate but not somatosensory cortex.

These findings provide direct experimental evidence in humans linking frontal-lobe limbic activity with pain affect, as originally suggested by early clinical lesion studies.

Functional MRI study of thalamic and cortical activations evoked by cutaneous heat, cold, and tactile stimuli.

Functional magnetic resonance imaging is used to locate discrete regions of the thalamus, insula, and second somatosensory cortex modulated during innocuous and noxious thermal stimulation and provides support for a role of the anterior insula and S2 in the perception of pain; whereas the posterior insula appears to be involved in tactile and innocuous temperature perception.