Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress.

  title={Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress.},
  author={Dennis S. Charney},
  journal={The American journal of psychiatry},
  volume={161 2},
  • D. Charney
  • Published 1 February 2004
  • Psychology
  • The American journal of psychiatry
OBJECTIVE Most research on the effects of severe psychological stress has focused on stress-related psychopathology. Here, the author develops psychobiological models of resilience to extreme stress. METHOD An integrative model of resilience and vulnerability that encompasses the neurochemical response patterns to acute stress and the neural mechanisms mediating reward, fear conditioning and extinction, and social behavior is proposed. RESULTS Eleven possible neurochemical, neuropeptide… 

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