Psychoactive drug use in evolutionary perspective.

@article{Nesse1997PsychoactiveDU,
  title={Psychoactive drug use in evolutionary perspective.},
  author={Randolph M. Nesse and Kent C. Berridge},
  journal={Science},
  year={1997},
  volume={278 5335},
  pages={
          63-6
        }
}
Pure psychoactive drugs and direct routes of administration are evolutionarily novel features of our environment. They are inherently pathogenic because they bypass adaptive information processing systems and act directly on ancient brain mechanisms that control emotion and behavior. Drugs that induce positive emotions give a false signal of a fitness benefit. This signal hijacks incentive mechanisms of "liking" and "wanting," and can result in continued use of drugs that no longer bring… Expand
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