Psychoactive constituents of cannabis and their clinical implications: a systematic review.

@article{CasajuanaKguel2018PsychoactiveCO,
  title={Psychoactive constituents of cannabis and their clinical implications: a systematic review.},
  author={Cristina Casajuana K{\"o}guel and Hugo L{\'o}pez-Pelayo and Mar{\'i}a Mercedes Balcells-Oliver{\'o} and Joan Colom and Antoni Gual},
  journal={Adicciones},
  year={2018},
  volume={30 2},
  pages={
          140-151
        }
}
Objective This systematic review aims to summarize current evidence on which naturally present cannabinoids contribute to cannabis psychoactivity, considering their reported concentrations and pharmacodynamics in humans. Design Following PRISMA guidelines, papers published before March 2016 in Medline, Scopus-Elsevier, Scopus, ISI-Web of Knowledge and COCHRANE, and fulfilling established a-priori selection criteria have been included. Results In 40 original papers, three naturally present… 

Tables from this paper

Cannabis sativa subsp. sativa’s pharmacological properties and health effects: A scoping review of current evidence
TLDR
Current evidence on hemp-specific interventions are still preliminary, with limited high quality clinical evidence for any specific therapeutic indication, mainly due to the wide variation in test item formulation, as the multiple variants of this plant differ in their phytochemical and bioactive compounds.
Biological effects of Cannabidiol on normal human healthy cell populations: Systematic review of the literature.
Identification of Psychoactive Metabolites from Cannabis sativa, Its Smoke, and Other Phytocannabinoids Using Machine Learning and Multivariate Methods
TLDR
This article aims to achieve this goal by application of batteries of computational tools such as machine learning tools and multivariate methods on physiochemical and absorption, distribution, metabolism, excretion, and toxicity descriptors of 468 metabolites from C. sativa, its smoke and, other phytocannabinoids.
Cannabinoids: from pot to lab
TLDR
Some of the novel aspects of cannabis and cannabinoids in relation to their legal situation, changes in their composition and forms of cannabis use, the concept of medical cannabis, and synthetic cannabinoids as new psychoactive substances (NPS) are reviewed.
An approach to the evaluation of the potency of cannabis resin in Madrid: a health hazard?
TLDR
The study shows that the THC content of most of the cannabis that can be purchased in Madrid region is over 15% and poses a health hazard, and demonstrates for the first time that only those samples with very high potency can be directly associated with certain organoleptic characteristics.
Serum Proteomic Analysis of Cannabis Use Disorder in Male Patients
TLDR
The work indicates that the differentially expressed serum proteins between CUD and control groups are correlated to liver X receptor/retinoid X receptor (RXR), farnesoid X receptors/rXR activation, and acute phase response signaling.
Investigation of DNA damage, oxidative stress, and inflammation in synthetic cannabinoid users
TLDR
It is concluded that SC can cause increase in oxidative stress and in inflammatory processes in addition to its potential for DNA damage.
Cannabinoids-Promising Antimicrobial Drugs or Intoxicants with Benefits?
  • P. Klahn
  • Biology, Medicine
    Antibiotics
  • 2020
TLDR
It is time to discuss whether cannabinoids are promising antimicrobial drug candidates or overhyped intoxicants with benefits.
Future Aspects for Cannabinoids in Breast Cancer Therapy
TLDR
Cannabinoids are already administered to breast cancer patients at advanced stages of the disease, but they might also be effective at earlier stages to decelerate tumor progression.
...
1
2
3
...

References

SHOWING 1-10 OF 91 REFERENCES
Chemistry, Metabolism, and Toxicology of Cannabis: Clinical Implications
TLDR
An attempt has been made to summarize the properties of cannabis and its derivatives, and to discuss the implications of its use with emphasis on bioavailability, limit of detection, carry over period and passive inhalation, important factors for detection and diagnosis.
Cannabidiol in Humans—The Quest for Therapeutic Targets
TLDR
Preliminary clinical trials suggest that high-dose oral CBD may exert a therapeutic effect for social anxiety disorder, insomnia and epilepsy, but also that it may cause mental sedation.
Cannabis: pharmacology and toxicology in animals and humans.
TLDR
The advent of highly potent analogs and a specific antagonist may make possible the development of compounds that lack undesirable side effects, thus limiting therapeutic usefulness of cannabinoid-derived drugs on the market today.
Oral Cannabidiol does not Alter the Subjective, Reinforcing or Cardiovascular Effects of Smoked Cannabis
TLDR
It is suggested that oral CBD does not reduce the reinforcing, physiological, or positive subjective effects of smoked cannabis, as well as the effect of oral THC on smoked cannabis administration.
Heat exposure of Cannabis sativa extracts affects the pharmacokinetic and metabolic profile in healthy male subjects.
TLDR
Results indicate that use of unheated extracts of C. SATIVA may lead to a beneficial change in metabolic pattern and possibly better tolerability.
The Pharmacologic and Clinical Effects of Medical Cannabis
TLDR
The pharmacology of cannabis, effects of various dosage formulations, therapeutics benefits and risks of cannabis for pain and muscle spasm, and safety concerns of medical cannabis use are described.
Sub-chronic impact of cannabinoids in street cannabis on cognition, psychotic-like symptoms and psychological well-being
TLDR
CBD attenuates the psychotic-like effects of cannabis over time in recreational users, and raises concerns for the harms stemming from use of varieties such as ‘skunk’ (sensimillia), which lack any CBD but currently dominate the supply of cannabis.
Cannabinoids: occurrence and medicinal chemistry.
TLDR
A survey of the more recent advances in both phytochemistry of C. sativa, the medicinal chemistry of cannabinoids, and their distribution in plants is given, highlighting the impact that research in these hot fields could have for modern medicinal chemistry and pharmacology.
...
1
2
3
4
5
...