Psychoactive Properties of Alpha-Methyltryptamine: Analysis From Self Reports of Users

  title={Psychoactive Properties of Alpha-Methyltryptamine: Analysis From Self Reports of Users},
  author={James Allen Wilcox},
  journal={Journal of Psychoactive Drugs},
  pages={274 - 276}
  • J. Wilcox
  • Published 1 July 2012
  • Psychology
  • Journal of Psychoactive Drugs
Abstract This is a retrospective examination of former users of alpha-methyltryptamine (AMT). A scale of questions was given to subjects who were familiar with the effects of AMT and the outcome was analyzed. Most subjects agreed that AMT had strong hallucinogenic qualities. The most common unwanted effects included anxiety, nausea and moderately severe dysphoria. Several subjects reported significant depression associated with use of AMT. Use of alpha-methyltryptamine could be dangerous in… 

Severe Serotonin Syndrome in an Autistic New Psychoactive Substance User After Consumption of Pills Containing Methoxphenidine and α-Methyltryptamine.

The patient tolerated the MAOI switch with no new adverse effects, and vitals remained within reference range (peak blood pressure was 138/87 mmHg during titration).

Novel psychoactive substances of interest for psychiatry

Novel psychoactive substances include synthetic cannabinoids, cathinone derivatives, psychedelic phenethylamines, novel stimulants, synthetic opioids, tryptamine derivatives, phencyclidine‐like

Toxicology and Analysis of Psychoactive Tryptamines

The morbidity accompanying tryptamine intake is considerable and it is critical for clinicians and laboratorians to be informed of the latest data on this public health threat.

Recreational Use, Analysis and Toxicity of Tryptamines

Information from Internet and from published scientific literature, organized in the way proposed in this review, provides an effective tool for specialists facing the emerging NPS threat to public health and public security, including the personnel working in Emergency Department.

Patterns of presentation and clinical toxicity after reported use of alpha methyltryptamine in the United Kingdom. A report from the UK National Poisons Information Service

Although still infrequent, toxicity following reported exposure to AMT has been encountered in the United Kingdom since January 2011 and Stimulant features, acute mental health disturbances and seizures are more frequently reported than in those presenting following reported use of mephedrone.

5-(2-Aminopropyl)indole (5-IT): a psychoactive substance used for recreational purposes is an inhibitor of human monoamine oxidase (MAO).

The inhibition of MAO-A suggests that 5-IT by itself or in combination with other substances may be able to potentiate serotonergic/monoaminergic effects and further studies are needed to clarify its relevance to the adverse effects reported.

New Psychoactive Substances

The emergence of new psychoactive substances (NPS) has become an increasing problem in recent years as they are designed to circumvent legislation. There has been an exponential rise in the number of

AMT (3-(2-aminopropyl)indole) and 5-IT (5-(2-aminopropyl)indole): an analytical challenge and implications for forensic analysis.

How subtle differences observed under mass spectral and UV conditions can help to facilitate the differentiation between the two isomers of 5-IT is illustrated.

Identification of (2-aminopropyl)indole positional isomers in forensic samples.

In 2012, 5-(2-aminopropyl)indole (5-API, 5-IT) was reported by Norwegian authorities to the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) via the Early Warning System (EWS). The 3-

(2-Aminopropyl)benzo[β]thiophenes (APBTs) are novel monoamine transporter ligands that lack stimulant effects but display psychedelic-like activity in mice

Overall, the data suggest that APBT isomers may exhibit psychedelic and/or entactogenic effects in humans, with minimal psychomotor stimulation.



Alpha-methyltryptamine revisited via easy Internet access.

A patient with sympathomimetic features who was found to have ingested AMT is reported, which is a synthetic hallucinogenic indolealkylamine that was initially studied as a monoamine oxidase inhibitor and used as an antidepressant.

Effects in normal man of α‐methyltryptamine and α‐ethyltryptamine

These drugs were compared objectively and subjectively in a group of trained, normal human volunteers and subjective effects were recorded 3 and 24 hours after administration of the drugs.

Fatality Due to Acute α-Methyltryptamine Intoxication

AMT is an indole analogue of amphetamine investigated in the 1960s as an antidepressant, stimulant, and monoamine oxidase inhibitor and today, AMT is recognized as a powerful psychedelic drug among high school and college-aged men and women.

Acute confusional state after designer tryptamine abuse

Gas chromatography‐mass spectrometry of urine revealed 5‐methoxy‐diisopropyltryptamine, 5‐METHoxy‐N‐methyltryptamines and an unidentified tryptamine, and identifying chemical products based solely on information of users is insufficient, and urinalysis is necessary in cases potentially involving designer drugs.


A potent site of action for MP-809 was found in the midbrain, a region possessing a strong adrenergic component, not likely that small changes in brain serotonin or in systemic blood pressure could account for the alterations in EEG produced by these two drugs.

Abuse Liability Profile of Three Substituted Tryptamines

DIPT and 5-MeO-DET may have abuse liability similar to known hallucinogens and may be hazardous because high doses produced activity and lethality, but were not similar to those of psychostimulants.

Indolealkylamine analogs share 5-HT2 binding characteristics with phenylalkylamine hallucinogens.

Schedules of controlled substances: placement of alpha-methyltryptamine and 5-methoxy-N,N-diisopropyltryptamine into schedule I of the Controlled Substances Act. Final rule.

  • Psychology
    Federal register
  • 2004
This final rule will continue to impose the regulatory controls and criminal sanctions of Schedule I substances on the manufacture, distribution, and possession of AMT and 5-MeO-DIPT.