Psychiatric symptoms with initiation of carbidopa‐levodopa treatment

@article{Lin1976PsychiatricSW,
  title={Psychiatric symptoms with initiation of carbidopa‐levodopa treatment},
  author={J T Lin and Dewey K. Ziegler},
  journal={Neurology},
  year={1976},
  volume={26},
  pages={699 - 699}
}
Two patients who had had no previous psychiatric symptoms became psychotic after their antiparkinsonism medication was changed from levodopa alone to a combination of levodopa and carbidopa, despite adherence to the appropriate and recommended dosage. Psychiatric symptoms disappeared after treatment with levodopa alone was resumed. 

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References

SHOWING 1-7 OF 7 REFERENCES

Carbidopa in Parkinson disease and in nausea and vomiting of levodopa.

Twenty Parkinson disease patients with long-standing nausea and vomiting and with major and stable improvement in parkinsonian symptoms participated in a double-blind trial of carbidopa, a

Modification of levodopa effect by systemic decarboxylase inhibition.

  • H. Mars
  • Medicine, Biology
    Archives of neurology
  • 1973
Twenty-five parkinsonian patients, previously receiving chronic levodopa therapy, were treated with a combination of levodopa and the peripheral carboxylase inhibitor, α-methyl dopa hydrazine

Enhanced response to low doses of levodopa after withdrawal from chronic treatment

Park insonian patients who respond to levodopa usually require weeks of therapy and graded increases of dose to levels of 2 to 4 gm. per day to show significant clinical benefit. ’ -4 They usually

MK 486 and levodopa in treatment of Parkinsonism.

Mars H: Modification of levodopa effects by systemic decarboxylase inhibition

  • Arch Neurol
  • 1973

Clinical studies of carbidopa and L-dopa in the treatment of Parkinson's disease

  • In Yahr MD (Editor): Advances in Neurology
  • 1973