Psychiatric symptoms with initiation of carbidopa‐levodopa treatment

  title={Psychiatric symptoms with initiation of carbidopa‐levodopa treatment},
  author={J T Lin and Dewey K. Ziegler},
  pages={699 - 699}
Two patients who had had no previous psychiatric symptoms became psychotic after their antiparkinsonism medication was changed from levodopa alone to a combination of levodopa and carbidopa, despite adherence to the appropriate and recommended dosage. Psychiatric symptoms disappeared after treatment with levodopa alone was resumed. 

Drug-Induced Mania - Causative Agents,Clinical Characteristics and Management

Steroids, levodopa and other dopaminergic agents, iproniazid, sympathomimetic amines, triazolobenzodiazepines and hallucinogens were the agents that most commonly induced manic syndromes.

Psychiatric side effects of medications prescribed in internal medicine

Several pharmacological treatments used in internal medicine can induce psychiatric side effects (PSEs) that mimic diagnoses seen in psychiatry, and these PSEs are often difficult to diagnose and can be very harmful to patients.

Drug-Induced Mania in the Elderly

It is uncertain if antidepressants cause mania or only increase the propensity for latent bipolar mania to be expressed, but the role of lithium in the treatment of other drug-induced manic episodes has not been studied adequately.

Consent for dental therapy in severely ill patients.

GPi pallidotomy for Parkinson's disease with drug-induced psychosis.

Drug-Induced Mania

Mania can occur by chance association during drug treatment, particularly in patients predisposed to mood disorder, and management involves discontinuation or dosage reduction of the suspected drug, and treatment of manic symptoms with anti-psychotic drugs or lithium.

Drug-Induced Nightmares

It appears that sedative/hypnotics, β-blockers, and amphetamines are the therapeutic modalities most frequently associated with nightmares, and these drug classes have a plausible pharmacologic mechanism to explain this effect.

Genetic disorders presenting as “schizophrenia”. Karl bonhoeffer's early view of the psychoses in the light of medical genetics

In this article, genetic disorders—chromosomal abnormalities and Mendelian diseases—are summarized that may be associated with psychoses that present as “schizophrenia” or are more or less similar to it.

Organic Delusions: Phenomenology, Anatomical Correlations, and Review

  • J. Cummings
  • Psychology, Medicine
    British Journal of Psychiatry
  • 1985
A prospective study of 20 consecutive patients with organic delusions revealed four general types of false beliefs: simple persecutory delusion, complex persecutory delusions, grandiose delusions, and those associated with specific neurological defects (anosognosia, reduplicative paramnesia).



Modification of levodopa effect by systemic decarboxylase inhibition.

  • H. Mars
  • Medicine, Biology
    Archives of neurology
  • 1973
Twenty-five parkinsonian patients, previously receiving chronic levodopa therapy, were treated with a combination of levodopa and the peripheral carboxylase inhibitor, α-methyl dopa hydrazine

Enhanced response to low doses of levodopa after withdrawal from chronic treatment

Park insonian patients who respond to levodopa usually require weeks of therapy and graded increases of dose to levels of 2 to 4 gm. per day to show significant clinical benefit. ’ -4 They usually

Carbidopa in Parkinson disease and in nausea and vomiting of levodopa.

Twenty Parkinson disease patients with long-standing nausea and vomiting and with major and stable improvement in parkinsonian symptoms participated in a double-blind trial of carbidopa, a

MK 486 and levodopa in treatment of Parkinsonism.

Mars H: Modification of levodopa effects by systemic decarboxylase inhibition

  • Arch Neurol
  • 1973

Clinical studies of carbidopa and L-dopa in the treatment of Parkinson's disease

  • In Yahr MD (Editor): Advances in Neurology
  • 1973