Psychiatric phenotype of the fragile X-associated tremor/ataxia syndrome (FXTAS) in males: newly described fronto-subcortical dementia.

@article{Bacalman2006PsychiatricPO,
  title={Psychiatric phenotype of the fragile X-associated tremor/ataxia syndrome (FXTAS) in males: newly described fronto-subcortical dementia.},
  author={Susan Bacalman and Faraz Farzin and James A Bourgeois and Jennifer B Cogswell and Beth L Goodlin-Jones and Louise W. Gane and Jim Grigsby and Maureen A. Leehey and Flora Tassone and Randi J. Hagerman},
  journal={The Journal of clinical psychiatry},
  year={2006},
  volume={67 1},
  pages={87-94}
}
OBJECTIVE The authors describe and quantify the neuropsychiatric symptoms present in a cohort of males with the fragile X mental retardation 1 (FMR1) premutation allele who have developed fragile X-associated tremor/ataxia syndrome (FXTAS). METHOD Fourteen male carriers of the FMR1 premutation who had clinical manifestations of the FXTAS syndrome and 14 age- and education-matched controls were assessed with the Neuropsychiatric Inventory (NPI), formal cognitive testing, and genetic analysis… CONTINUE READING