Psychiatric genetics: progress amid controversy

@article{Burmeister2008PsychiatricGP,
  title={Psychiatric genetics: progress amid controversy},
  author={Margit Burmeister and Melvin G. McInnis and Sebastian Z{\"o}llner},
  journal={Nature Reviews Genetics},
  year={2008},
  volume={9},
  pages={527-540}
}
Several psychiatric disorders — such as bipolar disorder, schizophrenia and autism — are highly heritable, yet identifying their genetic basis has been challenging, with most discoveries failing to be replicated. However, inroads have been made by the incorporation of intermediate traits (endophenotypes) and of environmental factors into genetic analyses, and through the identification of rare inherited variants and novel structural mutations. Current efforts aim to increase sample sizes by… 

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References

SHOWING 1-10 OF 170 REFERENCES

Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia

The results suggest that multiple, individually rare mutations altering genes in neurodevelopmental pathways contribute to schizophrenia, and disrupted genes disproportionately from signaling networks controlling neurodevelopment, including neuregulin and glutamate pathways.

Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology.

The pattern of findings emerging from genetic studies shows increasing evidence for an overlap in genetic susceptibility across the traditional classification categories-including association findings at DAOA(G72), DTNBP1 (dysbindin), COMT, BDNF, DISC1, and NRG1.

Molecular genetics of bipolar disorder.

  • N. CraddockI. Jones
  • Medicine, Psychology
    The British journal of psychiatry : the journal of mental science
  • 2001
It is almost certain that over the next few years the identification of bipolar susceptiblity genes will have a major impact on the understanding of disease pathophysiology.

Autism: in search of susceptibility genes.

The results of recent genetic linkage and candidate gene studies are reviewed in relation to the challenge of clinical and genetic heterogeneity, and prospects for the future of genetic research in autism are considered.

Molecular Mechanisms of Schizophrenia

Molecular findings suggest that a complex interplay between receptors, kinases, proteins and hormones is involved in schizophrenia and in a unifying hypothesis, different cascades merge into another that ultimately lead to the development of symptoms adherent to schizophrenic disorders.

Mapping autism risk loci using genetic linkage and chromosomal rearrangements

Linkage and copy number variation analyses implicate chromosome 11p12–p13 and neurexins, respectively, among other candidate loci, highlighting glutamate-related genes as promising candidates for contributing to ASDs.

Mouse models for psychiatric disorders.

Disease susceptibility genes for autism

Several genes have been proposed to play a role in susceptibility to autism and their potential role in the disorder are overviewed.

Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11.

The results show that a region of the genome that has been previously implicated by genetic linkage analysis can harbor genetic lesions that increase the susceptibility to schizophrenia.
...