Psychiatric disorders in 36 families with Wolfram syndrome.

  title={Psychiatric disorders in 36 families with Wolfram syndrome.},
  author={Ronnie Gorman Swift and Diana O. Perkins and Christopher Chase and Diego B. Sadler and Michael Swift},
  journal={The American journal of psychiatry},
  volume={148 6},
OBJECTIVE The purpose of this study was to test the hypothesis that heterozygous carriers of the gene for the Wolfram syndrome, who constitute about 1% of the population, are predisposed to significant psychiatric illness. The Wolfram syndrome is an autosomal recessive neurodegenerative syndrome in which 25% of the individuals who are homozygous for the condition have severe psychiatric symptoms that lead to suicide attempts or psychiatric hospitalizations. METHOD The authors collected… CONTINUE READING


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