Psychiatric disorders: A feat of epigenetic engineering

@article{Whalley2014PsychiatricDA,
  title={Psychiatric disorders: A feat of epigenetic engineering},
  author={Katherine Whalley},
  journal={Nature Reviews Neuroscience},
  year={2014},
  volume={15},
  pages={768-769}
}
  • K. Whalley
  • Published 1 December 2014
  • Psychology, Biology
  • Nature Reviews Neuroscience
Study uses in vivo gene-specific chromatin remodelling to elucidate the role of Fosb in addiction- and depression-related changes in the brain. 
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Paternal nicotine exposure defines different behavior in subsequent generation via hyper-methylation of mmu-miR-15b
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Nicotine exposure induced depression in the paternal generation, but reduced depression and promoted hyperactivity in F1 offspring, while this intergenerational effect was not passed down to the F2 generation.

References

Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors
TLDR
The mechanism linking chromatin dynamics to neurobiological phenomena is investigated by applying engineered transcription factors to selectively modify chromatin at a specific mouse gene in vivo and it is found that histone methylation or acetylation at the Fosb locus in nucleus accumbens, a brain reward region, was sufficient to control drug- and stress-evoked transcriptional and behavioral responses.