Psychiatric Morbidity in Survivors of the Acute Respiratory Distress Syndrome: A Systematic Review

  title={Psychiatric Morbidity in Survivors of the Acute Respiratory Distress Syndrome: A Systematic Review},
  author={Dimitry S. Davydow and Sanjay V Desai and Dale M. Needham and O. Joseph Bienvenu},
  journal={Psychosomatic Medicine},
Objective: Acute lung injury (ALI), including its more severe subcategory, acute respiratory distress syndrome (ARDS), is a critical illness associated with considerable morbidity and mortality. Our objective was to summarize data on the prevalence of depressive, posttraumatic stress disorder (PTSD), and other anxiety syndromes amongst survivors of ALI/ARDS, potential risk factors for these syndromes, and their relationships to quality of life. Methods: We conducted a systematic literature… 

Psychiatric Symptoms in Acute Respiratory Distress Syndrome Survivors: A 1-Year National Multicenter Study

Sociodemographic characteristics and in-ICU opioid administration, rather than traditional measures of critical illness severity, should be considered in identifying the patients at highest risk for psychiatric symptoms during recovery.

Psychiatric symptoms after acute respiratory distress syndrome: a 5-year longitudinal study

Clinically significant and long-lasting symptoms of anxiety, depression, and PTSD are common in the first 5 years after ARDS, and in-hospital screening of psychiatric history, including recent anxiety and depression symptoms, may be useful for long-term mental health treatment planning after AR DS.

Psychiatric morbidity in pediatric critical illness survivors: a comprehensive review of the literature.

Psychiatric morbidity appears to be a substantial problem for pediatric critical illness survivors and vulnerability factors, pediatric intensive care unit service-delivery characteristics, and severity of critical illnesses are associated with subsequent psychopathology.

Psychiatric complications (depression, anxiety disorders, post-traumatic stress disorder) of ARDS: a systematic review

This systematic review shows that depression, anxiety disorders and PTSD following ARDS are frequent, long-lasting, disabling and have severe psychiatric consequences.

Psychiatric Symptoms in Survivors of Acute Respiratory Distress Syndrome. Effects of Age, Sex, and Immune Modulation

6 months after ARDS, age, sex, illness severity, steroids, and GM‐CSF treatment were associated with psychiatric symptom scores, and these associations should be confirmed in a larger population.

Posttraumatic stress disorder in general intensive care unit survivors: a systematic review.

Posttraumatic stress disorder in survivors of acute respiratory distress syndrome (ARDS) and septic shock

From a clinical point of view prophylactic stress doses of hydrocortisone may reduce the major risk of PTSD associated with ALI / ARDS.

The long-lasting effects of the acute respiratory distress syndrome

Long term sequelae of ARDS commonly identified in the literature include long-term cognitive impairment, psychological morbidities, neuromuscular weakness, pulmonary dysfunction, and ongoing healthcare utilization with reduced quality of life.

Depressive Symptoms After Critical Illness: A Systematic Review and Meta-Analysis

Clinically important depressive symptoms occurred in approximately one-third of ICU survivors and were persistent through 12-month follow-up, and greater research into treatment is needed for this common and persistent post-ICU morbidity.

Depression in general intensive care unit survivors: a systematic review

Depressive symptoms are common in general ICU survivors and negatively impact HRQOL and future studies should address how factors related to individual patients, critical illness and post-ICU recovery are associated with depression.



Neuropsychological sequelae and impaired health status in survivors of severe acute respiratory distress syndrome.

A substantial portion of ARDS survivors exhibit impaired health status and cognitive sequelae which may be due to hypoxemia, emboli, inflammation, drug toxicity, and/or other etiologies one year after ARDS.

Quality of life after acute respiratory distress syndrome: a meta-analysis

ARDS survivors in different clinical settings experience similar decrements in QOL, and the precise magnitude of these decrements helps clarify the long-term prognosis for ARDS survivors.

Health-related quality of life and posttraumatic stress disorder in survivors of the acute respiratory distress syndrome.

Survivors of ARDS showed statistically significant impairments in all eight health dimensions of the SF-36 when compared with normal controls, and patients reporting multiple adverse experiences described the lowest health-related quality of life.

Health-related quality of life after acute lung injury.

It is concluded that long after lung injury, survivors have significantly lower health-related quality of life than the general population and are likely to have pulmonary and psychologic symptoms.

Two-year cognitive, emotional, and quality-of-life outcomes in acute respiratory distress syndrome.

The ARDS survivors had decreased quality of life, with the physical domains improving at 1 year, with no additional change at 2 years, and role emotional, pain, and general health did not change from hospital discharge to 2 years.

Social support during intensive care unit stay might improve mental impairment and consequently health-related quality of life in survivors of severe acute respiratory distress syndrome

HRQoL was reduced in long-term survivors, and was linked with an increased risk of chronic PTSD with ensuing psychological morbidity, independent of physical condition and was associated with traumatic memories of anxiety during their ICU stay.

One-year outcomes in survivors of the acute respiratory distress syndrome.

The absence of systemic corticosteroid treatment, the absence of illness acquired during the intensive care unit stay, and rapid resolution of lung injury and multiorgan dysfunction were associated with better functional status during the one-year follow-up.

Posttraumatic stress disorder and health-related quality of life in long-term survivors of acute respiratory distress syndrome.

Long-term survivors of acute respiratory distress syndrome seem to face a major risk of PTSD and major impairments in health-related quality of life in the long term.

Ventilatory management of acute lung injury and acute respiratory distress syndrome.

Volume- and pressure-limited ventilation strategies should be used in managing adult acute lung injury and acute respiratory distress syndrome patients, and barriers to widespread adoption are needed.

Sensitivity and specificity of a screening test to document traumatic experiences and to diagnose post-traumatic stress disorder in ARDS patients after intensive care treatment

An existing questionnaire for diagnosis of PTSD was modified and validated and found to be a responsive, valid and reliable instrument to screen survivors of intensive care for PTSD.