Psychiatric Manifestations of Graves’ Hyperthyroidism

  title={Psychiatric Manifestations of Graves’ Hyperthyroidism},
  author={Robertas Bunevic̆ius and Arthur J. Prange},
  journal={CNS Drugs},
Graves’ disease is an autoimmune disorder that is the most common cause of hyperthyroidism. Other symptoms associated with the disease are goitre, ophthalmopathy, and psychiatric manifestations such as mood and anxiety disorders and, sometimes, cognitive dysfunction. Graves’ hyperthyroidism may result in these latter manifestations via the induction of hyperactivity of the adrenergic nervous system.This review addresses the psychiatric presentations, and their pathophysiology and treatment, in… 

Graves' Hyperthyroidism Induced Acute Psychosis- A Case Study

Most patients with hyperthyroidism have a common constellation of symptoms which include insomnia, irritability, restlessness, fatigue, tremor, palpitations, increased perspiration, heat intolerance and weight loss despite a normal or increased appetite.

Graves’ Hyperthyroidism-Induced Psychosis Treated With Aripiprazole—A Case Report

It is reported the first known case on the use of aripriprazole to treat Graves’ hyperthyroidism-induced psychosis, and further studies examining the long-term effects and appropriate dose and duration of aripiprazole in this patient population are needed.

The mechanism of psychosis in a patient with Graves disease.

It may be suggested that psychotic symptoms in this case may occur due to thyroid hormones, autoantibody formation, a possible increase in dopamin release or brain NE disfunction that is triggered by Graves’ Disease.

Cutaneous Manifestations of Hyperthyroidism

It is my opinion that for isolated findings, such as onycholysis or palmoplantar hyperhidrosis, with an unremarkable review of systems, screening for hyperthyroidism is not mandatory, and it is appropriate to check a TSH level in a woman presenting with alopecia, even if there are no associated constitutional symptoms.

Hyperthyroidism : Incidence and long term quality-of-life

It is found that the results obtained with SF-36 were not related to the current serum levels of thyroid hormones, as subjects with suppressed S-TSH reported QoL scores above as well as below the average score for the general reference population in both physical component summary and mental component summary.

Periodic Paralysis and Encephalopathy as Initial Manifestations of Graves’ Disease: Case Report and Review of the Literature

This is the first reported coexistence of potentially treatable TPP and EAATD as initial neurological manifestations of Graves’ disease, thereby underscoring the necessity of suspicion of possible underlying Graves' disease in patients with acute paralysis and encephalopathy of unclear origin.

Antipsychotics in Hyperthyroid-Related Psychosis: Case Report and Systematic Review.

Choice of antipsychotic in hyperthyroid-related psychosis should be primarily based on side-effect profile and medical comorbidities, and risperidone is the optimal and seemingly effective choice for treating hyperthy thyroidopathy in an elderly thyrotoxic patient.

[Case of graves' disease with remarkable psychiatric symptoms].

A 42-year-old woman visited the authors' hospital with palpitations, excessive sweating, and finger tremors in March 2011, and her thyroid function showed improvement, but significant manic symptoms, irritability, hallucinations, and delusions were noted, and she was hospitalized for her own protection in May 2011.




It is apparent from this study that hyperthyroidism is a constitutional disease which may manifest any of the usual types of psychic reaction, and there is no type of psychic response that can be considered characteristic of hyperthy thyroidroidism.

Subclinical hyperthyroidism: clinical features and treatment options.

Evidence indicates that 'subclinical' hyperthyroidism reduces the quality of life, affecting both the psycho and somatic components of well-being, and produces relevant signs and symptoms of excessive thyroid hormone action, often mimicking adrenergic overactivity.

[Hyperthyroidism in the elderly: aspecific signs may cause a delay in diagnosis].

: The clinical manifestations of thyroid diseases in the elderly are often atypical and can easily be attributed to other medical conditions or 'normal aging'. Two nursing home patients with

Hyperthyreoïdie bij ouderen: aspecifieke symptomen kunnen leiden tot uitstel van de diagnose

Two nursing home patiënts with hyperthyroidism are described, due to the atypical presentation of the thyroid disease their complaints were attributed to other conditions and there was a significant delay in diagnosis and treatment.

Pathogenesis of Graves' disease: molecular analysis of anti-thyrotropin receptor antibodies.

Results of recent extended molecular analysis of TSHRAb are summarized and genetic components in Graves' disease are referred to, a disease in which multiple genetic and environmental factors are thought impair immunoregulation.

A survey study of neuropsychiatric complaints in patients with Graves' disease.

It is suggested that neuropsychiatric impairments are highly prevalent in Graves' disease, may lead to initial misdiagnosis or delays in diagnosis of the endocrine disorder, and may continue even once patients are believed to be euthyroid.

The management of hyperthyroidism.

  • J. Franklyn
  • Medicine, Biology
    The New England journal of medicine
  • 1994
Broad-spectrum immunosuppression, with all its side effects, is not the answer; more focused therapies to inhibit the immune response to specific thyroid antigens may represent the treatment of the future.

[A case of Hashimoto's encephalopathy associated with Graves' disease].

Therapy with steroids was started based on a diagnosis of Hashimoto's encephalopathy associated with Graves' disease, which definitely improved her clinical symptoms and anti-TPO antibodies disappeared in CSF and decreased in the serum after the treatment.

Clinical results of anti‐inflammatory therapy in Graves’ ophthalmopathy and association with thyroidal autoantibodies *

This retrospective study evaluated whether TSH binding inhibitory immunoglobulins (TBII) and thyroid stimulating antibodies (TSAb) are still associated with the clinical activity and severity of GO after the completion of anti‐inflammatory therapy and whether thyroid peroxidase (TPO) or thyroglobulin (TG) autoantibodies are in any way related to GO.