Psychedelics for the treatment of depression, anxiety, and existential distress in patients with a terminal illness: a systematic review.

@article{Schimmel2021PsychedelicsFT,
  title={Psychedelics for the treatment of depression, anxiety, and existential distress in patients with a terminal illness: a systematic review.},
  author={Nina Schimmel and Joost J Breeksema and Sanne Y. Smith-Apeldoorn and Jolien K E Veraart and Wim van den Brink and Robert A. Schoevers},
  journal={Psychopharmacology},
  year={2021}
}
BACKGROUND Terminally ill patients may experience existential distress, depression, or anxiety, limiting quality of life in the final stage. Existing psychotherapeutic or pharmacological interventions have (time) limited efficacy. Psychedelic treatment may be a safe and effective alternative treatment option. AIM Systematically review studies on psychedelic treatment with and without psychotherapy for existential distress, depression, and anxiety in terminally ill patients. METHODS Medline… 
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References

SHOWING 1-10 OF 73 REFERENCES
Therapeutic use of classic psychedelics to treat cancer-related psychiatric distress
  • S. Ross
  • Psychology, Medicine
    International review of psychiatry
  • 2018
TLDR
It is demonstrated that psychedelic-assisted treatment can produce rapid, robust, and sustained improvements in cancer-related psychological and existential distress.
MDMA-assisted psychotherapy for treatment of anxiety and other psychological distress related to life-threatening illnesses: a randomized pilot study
TLDR
Preliminary findings can inform development of larger clinical trials to further examine MDMA-assisted psychotherapy as a novel approach to treat individuals with LTI-related anxiety.
Psychedelic Treatments for Psychiatric Disorders: A Systematic Review and Thematic Synthesis of Patient Experiences in Qualitative Studies
TLDR
It is demonstrated how qualitative research of psychedelic treatments can contribute to distinguishing specific features of specific substances, and carry otherwise undiscovered implications for the treatment of specific psychiatric disorders.
Reviewing the Potential of Psychedelics for the Treatment of PTSD
TLDR
This review discusses 4 types of compounds: 3,4-methylenedioxymethamphetamine, ketamine, classical psychedelics (e.g., psilocybin and lysergic acid diethylamide), and cannabinoids, and describes the therapeutic rationale, the setting in which they are being administered, and their current state of evidence in the treatment of PTSD.
Long-term follow-up of psilocybin-assisted psychotherapy for psychiatric and existential distress in patients with life-threatening cancer
Background: A recently published randomized controlled trial compared single-dose psilocybin with single-dose niacin in conjunction with psychotherapy in participants with cancer-related psychiatric
Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial
TLDR
Psilocybin was associated with enduring anxiolytic and anti-depressant effects in patients with cancer-related psychological distress, sustained benefits in existential distress and quality of life, as well as improved attitudes towards death.
Integrating psychotherapy and psychopharmacology: psychedelic-assisted psychotherapy and other combined treatments
TLDR
The therapeutic mechanisms behind both conventional and psychedelic paradigms, including the evolution of this knowledge and the associated explanatory frameworks are reviewed, and how psychedelics have provided insights about psychiatric illnesses and treatments over the past decades are explored.
LSD-assisted psychotherapy for anxiety associated with a life-threatening disease: A qualitative study of acute and sustained subjective effects
TLDR
Evaluations of subjective experiences suggest facilitated access to emotions, confrontation of previously unknown anxieties, worries, resources and intense emotional peak experiences à la Maslow as major psychological working mechanisms in patients with life-threatening diseases.
Ketamine psychedelic therapy (KPT): a review of the results of ten years of research.
TLDR
A considerable increase in efficacy of the authors' standard alcoholism treatment when supplemented by ketamine psychedelic therapy (KPT) is demonstrated, and these psychological changes were shown to favor a sober lifestyle.
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