Psychedelics and the essential importance of context

@article{CarhartHarris2018PsychedelicsAT,
  title={Psychedelics and the essential importance of context},
  author={R. Carhart-Harris and L. Roseman and E. Haijen and D. Erritzoe and R. Watts and I. Branchi and M. Kaelen},
  journal={Journal of Psychopharmacology},
  year={2018},
  volume={32},
  pages={725 - 731}
}
  • R. Carhart-Harris, L. Roseman, +4 authors M. Kaelen
  • Published 2018
  • Psychology, Medicine
  • Journal of Psychopharmacology
  • Psychedelic drugs are making waves as modern trials support their therapeutic potential and various media continue to pique public interest. In this opinion piece, we draw attention to a long-recognised component of the psychedelic treatment model, namely ‘set’ and ‘setting’ – subsumed here under the umbrella term ‘context’. We highlight: (a) the pharmacological mechanisms of classic psychedelics (5-HT2A receptor agonism and associated plasticity) that we believe render their effects… CONTINUE READING
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    References

    SHOWING 1-10 OF 72 REFERENCES
    The Therapeutic Potential of Psychedelic Drugs: Past, Present, and Future
    • 132
    • PDF
    Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression
    • 101
    • PDF
    Psilocybin: Psychotherapy or drug?
    • G. Goodwin
    • Medicine
    • Journal of psychopharmacology
    • 2016
    • 5
    • PDF
    The hidden therapist: evidence for a central role of music in psychedelic therapy
    • 40
    • PDF
    Psychedelics in the treatment of unipolar mood disorders: a systematic review
    • 39
    • PDF
    LSD enhances suggestibility in healthy volunteers
    • 88
    • PDF
    Efficacy and Enlightenment: LSD Psychotherapy and the Drug Amendments of 1962
    • M. Oram
    • Psychology, Medicine
    • Journal of the history of medicine and allied sciences
    • 2014
    • 43
    • PDF
    Citalopram amplifies the influence of living conditions on mood in depressed patients enrolled in the STAR*D study
    • 19
    • PDF
    Psychedelics not linked to mental health problems or suicidal behavior: A population study
    • 109
    • PDF