Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels

@article{Madsen2019PsychedelicEO,
  title={Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels},
  author={Martin Korsbak Madsen and Patrick MacDonald Fisher and Daniel Burmester and Agnete Dyssegaard and Dea Siggaard Stenb{\ae}k and Sara Kristiansen and Sys Stybe Johansen and Sczabolz Lehel and Kristian Linnet and Claus Svarer and David Erritzoe and Brice Ozenne and Gitte Moos Knudsen},
  journal={Neuropsychopharmacology},
  year={2019},
  volume={44},
  pages={1328-1334}
}
The main psychedelic component of magic mushrooms is psilocybin, which shows promise as a treatment for depression and other mental disorders. Psychedelic effects are believed to emerge through stimulation of serotonin 2A receptors (5-HT2ARs) by psilocybin’s active metabolite, psilocin. We here report for the first time the relationship between intensity of psychedelic effects, cerebral 5-HT2AR occupancy and plasma levels of psilocin in humans. Eight healthy volunteers underwent positron… CONTINUE READING

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