Psychedelic Psychiatry’s Brave New World

@article{Nutt2020PsychedelicPB,
  title={Psychedelic Psychiatry’s Brave New World},
  author={David J. Nutt and David Erritzoe and Robin Lester Carhart-Harris},
  journal={Cell},
  year={2020},
  volume={181},
  pages={24-28}
}
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References

SHOWING 1-10 OF 18 REFERENCES
Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression
TLDR
The view that the quality of the acute psychedelic experience is a key mediator of long-term changes in mental health is bolstered, as data from a clinical trial assessing psilocybin for treatment-resistant depression confirmed this.
Illegal Drugs Laws: Clearing a 50-Year-Old Obstacle to Research
TLDR
The scientific community should challenge this pointless ban on medical drugs from research and clinical treatment and get governments to improve their regulations so science can flourish.
Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels
TLDR
It is reported for the first time that intake of psilocybin leads to significant 5-HT2AR occupancy in the human brain, and that both psilocin plasma levels and5-HT 2AR occupancy are closely associated with subjective intensity ratings, strongly supporting that stimulation of 5- HT2AR is a key determinant for the psychedelic experience.
Microdosing psychedelics: More questions than answers? An overview and suggestions for future research
TLDR
It is concluded that while most anecdotal reports focus on the positive experiences with microdosing, future research should also focus on potential risks of (multiple) administrations of a psychedelic in low doses, and (pre)clinical studies including biological as well as cognitive parameters have to be conducted to shed light on the potential negative consequencesmicrodosing could have.
Serotonin and brain function: a tale of two receptors
TLDR
This bipartite model purports to explain how different drugs (SSRIs and psychedelics) that modulate the serotonergic system in different ways, can achieve complementary adaptive and potentially therapeutic outcomes.
Emotions and brain function are altered up to one month after a single high dose of psilocybin
TLDR
It is suggested that psilocybin may increase emotional and brain plasticity, and the reported findings support the hypothesis that negative affect may be a therapeutic target for p silocybin.
The effects of chronic ritanserin treatment on sleep and the neuroendocrine response to l-tryptophan
TLDR
The results suggest that ritanserin causes a sustained effect on the5-HT mechanisms mediating SWS and on platelet 5-HT2 receptors, however, adaptation occurs to its effect on 5- HT-mediated neuroendocrine responses.
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