Therapeutic effects of classic serotonergic psychedelics: A systematic review of modern‐era clinical studies
- Psychology, MedicineActa psychiatrica Scandinavica
Although the main focus was on efficacy and safety, study characteristics, duration of antidepressants effects across studies, and the role of the subjective drug experiences were also reviewed and presented.
Psychedelic drugs as new tools in psychiatric therapeutics
- Psychology, MedicineRevista brasileira de psiquiatria
The successful results of MDMA-assisted psychotherapy for Brazilian patients with severe PTSD are reported, and this approach deserves attention from mental health professionals nationwide, since the prevalence of this disorder, which is already high, is likely to increase as COVID-19 infections and fatalities escalate in Brazil.
Medicinal psychedelics for mental health and addiction: Advancing research of an emerging paradigm
- PsychologyThe Australian and New Zealand journal of psychiatry
The sum of this research points towards medicinal psychedelics as a potential new class of psychiatric treatments when used within a medically supervised framework with integrated psychotherapeutic support, but before widespread translation into clinical use can occur, appropriately designed and sufficiently powered trials are required to detect both potential positive and negative outcomes.
From Psychiatry to Neurology: Psychedelics as Prospective Therapeutics for Neurodegenerative Disorders.
- Psychology, BiologyJournal of neurochemistry
Recent findings and information on how psychedelics may act therapeutically on cells within the central nervous system (CNS) during brain injuries and neurodegenerative diseases are discussed.
Psychedelic science in post-COVID-19 psychiatry
- Psychology, MedicineIrish Journal of Psychological Medicine
Preliminary evidence from the rapidly progressing field of psychedelic science shows psilocybin therapy offers a promising transdiagnostic treatment strategy for a range of disorders with restricted and maladaptive habitual patterns of cognition and behaviour, notably depression, addiction and obsessive compulsive disorder.
Psychedelics as an emerging novel intervention in the treatment of substance use disorder: a review.
- PsychologyMolecular biology reports
The aim of this review is to examine the current standing of evidence regarding psychedelic psychopharmacology and to provide an overview of the use and effectiveness of these drugs in the treatment of SUD, alcohol use disorder, and for smoking cessation.
The Subjective Effects of Psychedelics May Not Be Necessary for Their Enduring Therapeutic Effects.
- Psychology, MedicineACS pharmacology & translational science
Data is presented suggesting that the subjective effects induced by psychedelics may not be necessary to produce long-lasting changes in mood and behavior.
The promises and perils of psychedelic pharmacology for psychiatry.
- Psychology, BiologyNature reviews. Drug discovery
It is highlighted how basic science breakthroughs can guide the discovery and development of psychedelic-inspired medications with the potential for improved efficacy without hallucinogenic or rewarding actions.
The emerging role of psilocybin and MDMA in the treatment of mental illness
- Psychology, MedicineExpert review of neurotherapeutics
Evaluate the therapeutic potential of traditional psychedelics, psilocybin, and MDMA, in the treatment of mental illness with a narrative review of available literature to indicate a single-dose, rapid effect model that have robust effects with treatment-resistant mental disorders and a unique advantage as a possible monotherapy for mental illness.
Perspective: Can psychedelic-assisted therapy be a promising aid in compulsive sexual behavior disorder treatment?
- PsychologyComprehensive Psychiatry
SHOWING 1-10 OF 18 REFERENCES
Psychiatry & the psychedelic drugs. Past, present & future
- Psychology, MedicineNeuropharmacology
Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression
- PsychologyFront. Pharmacol.
The view that the quality of the acute psychedelic experience is a key mediator of long-term changes in mental health is bolstered, as data from a clinical trial assessing psilocybin for treatment-resistant depression confirmed this.
A systems model of altered consciousness: integrating natural and drug-induced psychoses
- Psychology, BiologyBrain Research Bulletin
Illegal Drugs Laws: Clearing a 50-Year-Old Obstacle to Research
- MedicinePLoS biology
The scientific community should challenge this pointless ban on medical drugs from research and clinical treatment and get governments to improve their regulations so science can flourish.
Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels
- Psychology, MedicineNeuropsychopharmacology
It is reported for the first time that intake of psilocybin leads to significant 5-HT2AR occupancy in the human brain, and that both psilocin plasma levels and5-HT 2AR occupancy are closely associated with subjective intensity ratings, strongly supporting that stimulation of 5- HT2AR is a key determinant for the psychedelic experience.
Microdosing psychedelics: More questions than answers? An overview and suggestions for future research
- MedicineJournal of psychopharmacology
It is concluded that while most anecdotal reports focus on the positive experiences with microdosing, future research should also focus on potential risks of (multiple) administrations of a psychedelic in low doses, and (pre)clinical studies including biological as well as cognitive parameters have to be conducted to shed light on the potential negative consequencesmicrodosing could have.
The Fabric of Meaning and Subjective Effects in LSD-Induced States Depend on Serotonin 2A Receptor Activation
- Psychology, BiologyCurrent Biology
Serotonin and brain function: a tale of two receptors
- PsychologyJournal of psychopharmacology
This bipartite model purports to explain how different drugs (SSRIs and psychedelics) that modulate the serotonergic system in different ways, can achieve complementary adaptive and potentially therapeutic outcomes.
Emotions and brain function are altered up to one month after a single high dose of psilocybin
- Psychology, BiologyScientific Reports
It is suggested that psilocybin may increase emotional and brain plasticity, and the reported findings support the hypothesis that negative affect may be a therapeutic target for p silocybin.
The effects of chronic ritanserin treatment on sleep and the neuroendocrine response to l-tryptophan
- Biology, PsychologyPsychopharmacology
The results suggest that ritanserin causes a sustained effect on the5-HT mechanisms mediating SWS and on platelet 5-HT2 receptors, however, adaptation occurs to its effect on 5- HT-mediated neuroendocrine responses.