PspK of Streptococcus pneumoniae increases adherence to epithelial cells and enhances nasopharyngeal colonization.

@article{Keller2013PspKOS,
  title={PspK of Streptococcus pneumoniae increases adherence to epithelial cells and enhances nasopharyngeal colonization.},
  author={Lance E. Keller and Christina Violeta Jones and Justin A. Thornton and Martin E. Sanders and Edwin Swiatlo and Moon H Nahm and In Ho Park and Larry S McDaniel},
  journal={Infection and immunity},
  year={2013},
  volume={81 1},
  pages={
          173-81
        }
}
Streptococcus pneumoniae (the pneumococcus) colonizes the human nasopharynx and can cause invasive disease aided by the pneumococcal capsule. Group II nontypeable S. pneumoniae (NTSp) lacks a polysaccharide capsule, and a subgroup of NTSp carriage isolates has been found to have a novel gene, pneumococcal surface protein K (pspK), which replaces the capsule locus. A recent rise in the number of NTSp isolates colonizing the human nasopharynx has been observed, but the colonization factors of… CONTINUE READING

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