Psoriatic cutaneous inflammation promotes human monocyte differentiation into active osteoclasts, facilitating bone damage.

@article{Raimondo2017PsoriaticCI,
  title={Psoriatic cutaneous inflammation promotes human monocyte differentiation into active osteoclasts, facilitating bone damage.},
  author={A. Raimondo and Serena Lembo and Roberta di Caprio and Giovanna Donnarumma and Giuseppe Monfrecola and N Balato and Fabio Ayala and Anna Balato},
  journal={European journal of immunology},
  year={2017},
  volume={47 6},
  pages={1062-1074}
}
Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy that can be associated with focal bone erosions. Psoriasis usually precedes the psoriatic arthritis onset by an average of 10 years, but this relation is not yet fully elucidated. Pro-inflammatory cytokines, such as IL-33, OPN, IL-17, and TNF-α are involved in both psoriasis and PsA pathogenesis as well as in bone homeostasis. In this study, we have demonstrated that IL-33, OPN, IL-17, and TNF-α induced the release of a wide range… CONTINUE READING

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